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临床试验/NCT06380998
NCT06380998尚未招募不适用

Effects of Petroleum Compounds on Psychological Health, Cognitive Functions, and the Possible Ameliorating Effect of Whey Protein in a Sample of Petrol Station Workers in Assiut Governorate

Assiut University1 个研究点 分布在 1 个国家目标入组 196 人开始时间: 2024年10月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
196
试验地点
1
主要终点
Effects of petroleum compounds on psychological health and cognitive functions of petrol station workers in Assiut

研究概览

简要总结

Over the last decade, awareness of the effects of hydrocarbon fuels on neurodegenerative disorders has increased significantly, as they are ubiquitous environmentally toxic chemicals that affect the central nervous system and result in irreversible neuronal damage, as many hydrocarbons can cross the blood-brain barrier through multiple pathways and cause direct toxicity.

详细描述

Petrol stations are establishments that retail liquid fuels derived from petroleum, alcohol, and other automotive fuels, with equipment available for their measurement and storage. This process, linked to gasoline distribution, can be a significant source of volatile organic compounds (VOCs), such as benzene, toluene, ethylbenzene, and xylene isomers (BTEX), the primary volatile hydrocarbons derived from petroleum.

Headache, fatigue, dizziness, respiratory tract infections, skin allergies, eye infections, and impairment of memory have been experienced by a few people immediately following exposure to some solvents. CNS depression is a common physiological outcome caused by high exposure to some VOCs. General anaesthetic effects, and as a most severe outcome, unconsciousness and, in some cases, death, may occur at the end.

Long-term exposure to organic solvents may cause permanent central nervous system disturbances, a condition called chronic solvent encephalopathy (CSE).

Cognitive symptoms and neuropsychological signs, or issues with memory, focus, and learning, are the hallmarks of CSE, which is underdiagnosed and characterized by these symptoms as well as possible side effects like headaches, fatigue, balance issues, and mild depression. If exposure stops, though, the illness will not worsen.

We are discovering more about the importance of nutrition and its impact on an individual's susceptibility to illness progression. Diet has been suggested to have an important role in cognitive health and the development of dementia. However, most of the intervention studies conducted to date have mainly assessed the effect of dietary supplements on cognitive function.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 50 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Workers in direct contact with petroleum compounds in petroleum stations.
  • Working for at least 8 continuous hours daily for at least 2 years before enrollment in the study.
  • Participants have willingness to participate and have no history for substance abuse

排除标准

  • Working for less than 2 years with interrupted exposure.
  • The exposure of workers to petroleum compounds is indirect.
  • History of psychological and neurodegenerative diseases before starting this job.
  • Patients with medical conditions like renal or cardiovascular diseases.
  • Individuals with known allergies or contraindications to study supplements.

结局指标

主要结局

Effects of petroleum compounds on psychological health and cognitive functions of petrol station workers in Assiut

时间窗: 1 year

for psychological assessment through symptom check list 90 (revised) and cognitive function through the Mini Mental State Examination (30 points: 25-30: normal; 21-24: mild cognitive impairment; 10-20: moderate; and 0-9: severe) and Wecksler memory scale (higher score indicates better performance, while lower score indicates memory impairment)

To explore the role of supplements with whey protein in ameliorating these effects

时间窗: 1 year

20 g of whey protein 3 times per week for 8 weeks will be given to workers with cognitive difficulties

To explore the relation between the level of petroleum hydrocarbon metabolites and the severity of psychological heath and cognitive functions disturbance of petrol station workers

时间窗: 1 year

urinary metabolites for BTEX through GS-MS

次要结局

  • To assess the relationship between the psychological effects, cognitive functions, and nutritional status of petroleum station workers(1 year)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Gehad Hussien Eisa

Assiut University, Faculty of medicine, Forensic medicine and clinical toxicology department, lecturer assistant

Assiut University

研究点 (1)

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