Effect of clozapine and olanzapine on the use of drugs and alcohol by patients with schizophrenia and related disorders
- Conditions
- schizophreniasubstance abuse or dependenceclozapineolanzapinedouble blindrandomized
- Registration Number
- NL-OMON21845
- Lead Sponsor
- ZonMW
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 140
Inclusion Criteria
1. Diagnosis of schizophrenia or schizoaffective disorder or schizophreniform disorder according to DSM-IV with
the Structured Clinical Interview for the Diagnostic and
Statistical Manual of Mental Disorders (SCID-P)
Exclusion Criteria
Detailed exclusion criteria
1. Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary efficacy measures: <br /><br>at baseline, week 4, week 8, month 6 and at moment of unblinding:<br /><br>Self reported drug use<br /><br>- CIDI SAM: self-report substance use <br /><br>- Recent Drug Use Urinalysis (RDUU): a laboratory semiquantitative test on the presence of cannabis, heroin,cocaine and amphetamines (including XTC)<br>
- Secondary Outcome Measures
Name Time Method