3 Tesla (3T) Stroke Medical Radiologic Technology (MRT) for Examining Mismatch in 1000+

Completed

• Conditions: Acute Stroke; Transient Ischemic Attack

• Registration Number: NCT00715533
• Lead Sponsor: Charite University, Berlin, Germany

Brief Summary

The purpose of this study is to compare clinical and economic parameters of stroke patients who have received acute MRI imaging (test group) to patients who have received routine CT imaging (control group) in the clinical setting of acute stroke.

Detailed Description

The primary objective:

* Prospective validation of infarct development in ischemic stroke and transitory ischemic attacks on the basis of all patients given a preliminary diagnosis of stroke or TIA in the emergency ward of the Benjamin Franklin Campus of Charité-Universitätsmedizin Berlin.

Secondary objectives:

* Determination of the spontaneous reperfusion rate in patients with an initial mismatch in the correlation between the time from onset of symptoms to the time of first imaging and NIHSS score severity

* Characterization of metabolic changes in ischemic tissue in cases of minor subcortical infarct using high resolution diffusion weighted MRI (DWI) and perfusion MRI with 2nd pass corrected CBF cards

* Proof of the principle that stroke MRI can improve patient care / shorten the period in which patients are bedridden

* Measurement of the diffusion tensor in acute ischemic stroke (Hamburg DTI study)

* Proof of structural damage and investigation of pathogenesis in patients suffering from clinical transitory ischemic attacks (TIA)

* Investigation of the correlation of clinical symptoms and lesion site as well as of changes in cortical plasticity in patients with solitary thalamus infarct

* Brain plasticity and motor learning in cases of a purely cortical infarct

* Characterization of gender specific damage patterns in stroke

* Morphologic and pathophysiological typing of the cryptic and cardial embolic infarct in correlation to incidence of arrhythmia

* Characterization of localization and morphology of infarcts in patients presenting in the emergency ward with central vestibular nerve syndrome / recording frequency of cerebral sessions in patients presenting with a primary diagnosis of central vestibular nerve lesion

* Clinical characterization of cerebellar and brain stem infarcts which are accompanied by vertigo symptoms and their correlation to infarct location

Study Timeline

• Study Start: 2008-07
• Study First Submitted: 2008-07-11
• Study First Submitted QC: 2008-07-11
• Study First Posted: 2008-07-15
• Primary Completion: 2013-07
• Study Completion: 2013-07
• Status Verified: 2014-06
• Last Update Submitted: 2014-06-23
• Last Update Posted: 2014-06-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1500

Inclusion Criteria

• Suspected stroke or TIA within 24 hours from symptom onset

Exclusion Criteria

• MRI contraindication

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
change of infarct size between baseline and day 6	day 6

Secondary Outcome Measures

Name	Time	Method
clinical score (modified Rankin Scale)	day 90

Trial Locations

Locations (1)

Center for Stroke Research Berlin, Neurology, Charité Campus Benjamin Franklin; 🇩🇪 Berlin, Germany