The Efficacy of Aldehyde Dehydrogenase (ALDH) Enzyme in Chemotherapy-Related Fatigue with Advanced Gastrointestinal Cancer Patients: A Single-Center Study

Korea University Anam Hospital0 个研究点目标入组 82 人开始时间: 待定最近更新: 2024年3月4日

适应症

试验速览

暂无简介。

•To be included in the trial, subjects must meet all of the following criteria:
•1.Fatigue score = 4 on analog scale of 0 to 10 (0; not at all, 10; worst possible fatigue) for more than 1 week.
•2.Subject has willing and able to written informed consent form (ICF) prior to any screening procedures.
•3.Age = 19 years old of male and female.
•4.Life expectancy more than 3 months.

•1.Hb < 8g/dL
•2.Uncontrolled hyper- or hypothyroidism despite of appropriate treatment
•3.Evidence of central nervous system (CNS) tumor metastasis; permitted if asymptomatic or neurologically stable.
•4.Sign of active and uncontrolled bacterial or viral infection requiring systemic therapy
•5.Abnormal cognition status or psychiatric disease.
•6.Anamnesis of hypersensitivity reaction to the ALDH enzyme.
•7.Current use or previous use within 14 days of the following medications: Korean-Chinese medications, methylphenidate, modafinil, phenobarbital, diphenylhydantoin, primidone, phenylbutazone, monoamine oxidase inhibitors, clonidine, and tricyclic antidepressants.
•8.Medical conditions that could affect trial outcomes or subjects who were considered unsuitable for trial enrollment by the investigator.

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