Electronic cigarettes: Nicotine delivery in users

Not Applicable

Completed

• Conditions: Smoking Cessation; Mental and Behavioural Disorders; Nicotine addiction

• Registration Number: ISRCTN39500419
• Lead Sponsor: Queen Mary, University of London (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-06-26
• Study Completion: 2017-06-25
• Last Update Posted: 10 December 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

1. Aged 18 or over
2. Experienced EC users (using EC daily for at least one month) who still smoke conventional cigarettes at least occasionally
3. Willing to attend a series of morning sessions and provide blood samples

Exclusion Criteria

1. Pregnant or breastfeeding
2. Current serious illness
3. Enrolled in other research

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
PK characteristics of each EC brand.

Secondary Outcome Measures

Name	Time	Method
<br> 1. Comparisons between each brand and conventional cigarette<br> 2. Ranking of brands in Cmax (the highest drug concentration observed in plasma following EC use)<br> 3. Tmax (time at which the highest nicotine concentration occurred in plasma following EC use)<br> 4. AUC (estimated area under the plasma nicotine curve concentration)<br> 5. User ratings<br>