Schema-Focused Therapy for Chronic Depression: Efficacy and Mechanisms of Change

Completed

Conditions: Despondency
Gloominess
10027946

Registration Number: NL-OMON34720

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 27

Inclusion Criteria

Diagnosis of current chronic major depressive disorder (meeting criteria of major depressive disorder for at least 2 years); Beck Depression Inventory II score at screening ><=20; age range 18-65, can understand and speak the Dutch language.

Exclusion Criteria

Acute suicide risk; the depression is due to a physical illness, medication intake, substance or drug abuse; comorbid autism spectrum disorder; presence of any cluster A or cluster B personality disorder.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main outcome variable is change in severity of depressive symptoms during<br /><br>the intervention phase as assessed by the Beck Depression Inventory II (BDI-II)<br /><br>and the presence or absence of chronic major depressive disorder as assessed by<br /><br>the Structured Clinical Interview for DSM-IV (SCID 1) at the end of treatment<br /><br>and at 12 months follow-up.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Further variables in this study are:<br /><br><br /><br>Cognitive measures: Attributional Styles Questionnaire (ASQ), Core beliefs<br /><br>Visual Analogue Scale (VAS), Dysfunctional Attitudes Scale (DAS), Schema<br /><br>Questionnaire (SQ), Schema Mode Inventory (SMI).<br /><br><br /><br>Interpersonal Measures: Inventory of Interpersonal Problem *Circumplex (IIP-C),<br /><br>Relationships Scales Questionnaire (RSQ).<br /><br><br /><br>Therapeutic Alliance: Working Alliance Inventory Client Version (WAI-C).<br /><br><br /><br>Measures of Self-Esteem: Rosenberg Self-Esteem Scale (RSE), Single Category<br /><br>Implicit Association Test (SC-IAT).<br /><br><br /><br>Emotional Experiences: Positive and Negative Affect Scale (PANAS).<br /><br><br /><br>Other Measures: Blood oxygen level dependent (BOLD) response (measured using<br /><br>fMRI), Structured Clinical Interview for DSM-IV Axis II (SCID2), Childhood<br /><br>Trauma Questionnaire (CTQ).</p><br>