Role of two regimens (3 vs 7 days) of corticosteroids in septic shock
Not Applicable
Not yet recruiting
- Conditions
- Health Condition 1: null- Septic Shock
- Registration Number
- CTRI/2012/08/002866
- Lead Sponsor
- Post Graduate Institute of Medical Education and Research Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 238
Inclusion Criteria
1.Patients aged more 18 years with diagnosis of refractory septic shock
2.Within 24 hour of diagnosis of sepsis/septic shock; and
3.Who give consent for participation in the study, are eligible for inclusion in the study
Exclusion Criteria
1.Patients who are already receiving systemic corticosteroids at the time of screening.
2.Patients who require corticosteroids for longer duration such interstitial lung diseases, rheumatological diseases, exacerbation of asthma/COPD etc.
3.Immune compromised patients â?? cancers, HIV or prior history of corticosteroids use.
4.Patients who refuse to participate in the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome: <br/ ><br>Overall reversal of the shock. <br/ ><br>Secondary outcomes: <br/ ><br>Reversal of shock on day-3 and day-7, in-hospital mortality, day-28 mortality, duration vasopressors requirement, and complication rates such as hyper-glycaemia, super infection and neuromuscular weakness. <br/ ><br>Timepoint: Day 3 <br/ ><br>Day 7 <br/ ><br>At the time of discharge
- Secondary Outcome Measures
Name Time Method Reversal of shock on day-3 and day-7, in-hospital mortality, day-28 mortality, duration vasopressors requirement, and complication rates such as hyper-glycaemia, super infection and neuromuscular weakness. <br/ ><br>Timepoint: Day 3 <br/ ><br>Day 7 <br/ ><br>At the time of discharge