The Effects of Dexmedetomidine on Segmental EEG Power Spectra Activity Under Propofol-based Anesthesia
试验速览
- 阶段
- 不适用
- 发起方
- Zhiyi Zuo
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- EEG power spectra
研究概览
简要总结
To compare the EEG power spectra activity during propofol-based anesthesia in the presence or absence of dexmedetomidine in patients undergoing hysteroscopic examination and surgery to determine whether the addition of dexmedetomidine will induce better sleep-like anesthesia status.
详细描述
Three groups of patients undergoing hysteroscopic examination and surgery will be studied: 1) control group, patients will receive propofol intravenous infusion to provide anesthesia; 2) dexmedetomidine 0.5 microgram/kg group. This dexmedetomidine dose is infused within 10 min and then the use of propofol for anesthesia; and 3) dexmedetomidine 1 microgram/kg group. This dexmedetomidine dose is infused within 10 min and then the use of propofol for anesthesia.
Each group will have 20 patients.
General conditions including blood pressure, respiration, and heart rates will be recorded.
EEG power spectra activity will be recorded no-invasively by a Narcotrend EEG monitor.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists Physical status I to II grade.
- •body mass index 18 to 25 kg/m2
- •no vision or hearing impairment
- •will receive general anesthesia
排除标准
- •with psychological or mental diseases
- •with neurological diseases
- •treating with steroids or with alcohol dependence.
结局指标
主要结局
EEG power spectra
时间窗: From prior to anesthesia to 10 min after anesthesia.
EEG power spectra monitored no-invasively by Narcotrend
次要结局
- Blood pressure(From prior to anesthesia to 10 min after anesthesia.)
- Respiration(From prior to anesthesia to 10 min after anesthesia.)
- Heart rates(From prior to anesthesia to 10 min after anesthesia.)