Dexmedetomidine on Segmental EEG Power Spectra

• Conditions: EEG Power Spectra; Anesthesia

• Registration Number: NCT03515876
• Lead Sponsor: Zhiyi Zuo

Brief Summary

To compare the EEG power spectra activity during propofol-based anesthesia in the presence or absence of dexmedetomidine in patients undergoing hysteroscopic examination and surgery to determine whether the addition of dexmedetomidine will induce better sleep-like anesthesia status.

Detailed Description

Three groups of patients undergoing hysteroscopic examination and surgery will be studied: 1) control group, patients will receive propofol intravenous infusion to provide anesthesia; 2) dexmedetomidine 0.5 microgram/kg group. This dexmedetomidine dose is infused within 10 min and then the use of propofol for anesthesia; and 3) dexmedetomidine 1 microgram/kg group. This dexmedetomidine dose is infused within 10 min and then the use of propofol for anesthesia.

Each group will have 20 patients.

General conditions including blood pressure, respiration, and heart rates will be recorded.

EEG power spectra activity will be recorded no-invasively by a Narcotrend EEG monitor.

Study Timeline

• Study Start: 2018-04-19
• Study First Submitted: 2018-04-23
• Study First Submitted QC: 2018-04-23
• Study First Posted: 2018-05-04
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-05
• Last Update Posted: 2019-04-09
• Primary Completion: 2019-06
• Study Completion: 2019-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• American Society of Anesthesiologists Physical status I to II grade.
• body mass index 18 to 25 kg/m2
• no vision or hearing impairment
• will receive general anesthesia

Exclusion Criteria

• with psychological or mental diseases
• with neurological diseases
• treating with steroids or with alcohol dependence.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
EEG power spectra	From prior to anesthesia to 10 min after anesthesia.	EEG power spectra monitored no-invasively by Narcotrend

Secondary Outcome Measures

Name	Time	Method
Blood pressure	From prior to anesthesia to 10 min after anesthesia.	Blood pressure monitored no-invasively
Respiration	From prior to anesthesia to 10 min after anesthesia.	Monitored no-invasively
Heart rates	From prior to anesthesia to 10 min after anesthesia.	Monitored no-invasively

Trial Locations

Locations (1)

Sun Yat-Sen Memorial Hospital; 🇨🇳 Guangzhou, Guangdong, China