The Effect of Curcumin Supplementation on Recovery From Exercise-induced Muscle Damage

Not Applicable

• Conditions: Exercise Induced Muscle Damage
• Interventions: Dietary Supplement: Curcumin

• Registration Number: NCT05346211
• Lead Sponsor: St Mary's University College

Brief Summary

Recent evidence suggests that curcumin supplementation may reduce muscle inflammation, oxidative markers, and muscle damage. The most favourable dosage to elicit these ergogenic effects are yet to be established; both 750mg \& 1500mg has been shown to be effective. Curcumin supplementation has been ingested in numerous different ways however, no previous research to date has used curcumin in a hydrolysed (drinkable) format. The aim of this study is to investigate whether hydrolysed curcumin can reduce indices of muscle damage and improve recovery, whilst also examining a potential dose-response effect.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-04
• Study First Submitted: 2022-04-12
• Study First Submitted QC: 2022-04-19
• Last Update Submitted: 2022-04-19
• Study First Posted: 2022-04-26
• Last Update Posted: 2022-04-26
• Study Start: 2022-05-01
• Primary Completion: 2022-09-30
• Study Completion: 2023-09-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

Inclusion criteria are as follows:

• between the age of 18-35
• non-smoker
• no previous history of cardiovascular, respiratory, or neurological problems
• not taking anticoagulant medication
• injury-free in the 3 months prior to scheduled participation in the study

Exclusion Criteria

Exclusion criteria include:

• hypertension (<140/80)
• any blood diseases or clotting issues,
• injury, or previous injury in <3 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Curcumin Single	Curcumin	The Single dose group will consume 1 placebo sachet and one curcumin sachet per day. Curcumin supplementation will be from YourZooki, the supplement in question is commercially offered to the public in a tangerine flavour. The sachets will be in 750mg hydrolysed format. The placebo is a sachet containing the same ingredients mentioned above minus the curcumin. The sachets will be in 750mg hydrolysed format. Supplementation will be administered and commence 48-hours prior to the first testing day and will be consumed twice a day (8am \& 8pm).
Curcumin Double	Curcumin	The double dose group will consume two sachets per day of curcumin. Curcumin supplementation will be from YourZooki, the supplement in question is commercially offered to the public in a tangerine flavour. The sachets will be in 750mg hydrolysed format. Supplementation will be administered and commence 48-hours prior to the first testing day and will be consumed twice a day (8am \& 8pm).

Primary Outcome Measures

Name	Time	Method
Blood markers	72 hours post	Blood samples will be taken for analysis of markers of IL-6, IL-1β, TNF-α, IL-1, IL-4, IL-10 and CK will be taken
Soreness	72 hours post	Pressure pain threshold
Ford and Fort	72 hours post	Capillary sample Ford and Fort tests
Muscle Structure	72 hours post	Muscle swelling - thigh girth + Ultrasound measurement
Muscle Function	72 hours post	Muscular endurance