Mediating Role of Intraoperative Red Blood Cell Transfusion in the Relationship Between Preoperative Anaemia and Postoperative Complications in Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 13,683
- 试验地点
- 1
- 主要终点
- Incidence of Postoperative Complications
研究概览
简要总结
This study investigates the mediating role of intraoperative allogeneic red blood cell transfusion in the relationship between preoperative anaemia and postoperative complications in patients undergoing cardiac surgery. Using mediation analysis methods, we aim to determine whether and to what extent intraoperative transfusion explains the association between preoperative anaemia and adverse postoperative outcomes. By elucidating this pathway, the study seeks to inform perioperative blood management strategies and support more personalized, risk-adapted approaches to minimize postoperative complications in anaemic patients undergoing cardiac procedures.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 and older ；
- •Undergoing elective cardiac surgery with cardiopulmonary bypass
排除标准
- •preoperative mechanical circulatory support
- •ASA physical status VI-V
- •unplanned intra-hospital reoperations
- •catheter-based valve replacements,
- •heart tumours,
- •stent implantation surgeries,
- •coronary angiography,
- •transvascular valve clamping,
- •tetralogy of Fallot,
- •ventricular aneurysms,
- •cardiomyopathies,
结局指标
主要结局
Incidence of Postoperative Complications
时间窗: From the start of surgery to 30 days after surgery
The primary outcome is the occurrence of any postoperative complications during the index hospitalization. Complications include, but are not limited to, acute kidney injury (AKI), neurological complications, infections, and pulmonary complications. These are assessed using standardized diagnostic criteria.
次要结局
- Incidence of Acute Kidney Injury (AKI)(From the start of surgery to 30 days after surgery)
- Length of Hospital Stay(From the start of surgery to 30 days after surgery)
- Incidence of Neurological Complications(From the start of surgery to 30 days after surgery)
- Incidence of Pulmonary Complications(From the start of surgery to 30 days after surgery)
- Incidence of Infections(From the start of surgery to 30 days after surgery)
- Total Hospitalization Cost(From the start of surgery to 30 days after surgery)