Imaging Inflammation in Alzheimer's Disease With 11C-ER176
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- 11C-ER176 Total Distribution Volume
研究概览
简要总结
This study is being done to learn about inflammation in the brain of those with Alzheimer's disease (AD). The purpose of this study is to determine if 11C-ER176 is able to accurately measure inflammation in patients with Alzheimer's disease. Both patients (with either mild cognitive impairment (MCI) or Alzheimer's disease) and healthy controls (participants without memory complaints or impairment) will be included in this study.
详细描述
Inflammation likely plays a role in the damage to the brain caused by Alzheimer's disease.
Accurately measuring inflammation in the brain could provide new information about the mechanisms that cause Alzheimer's disease, and could help identify new treatments that reduce inflammation. Positron emission tomography (PET) imaging is a type of brain scanning method that allows investigators to measure small molecules in the brain. ER176-PET was recently developed as an improved method for measuring brain inflammation. However, ER176-PET has not yet been used in patients with Alzheimer's disease. The investigators propose to use ER176-PET imaging in subjects with mild cognitive impairment (a very early stage of Alzheimer's disease) or mild Alzheimer's disease to compare the amount of inflammation with that seen in older control subjects. The investigators will first use a "gold standard" method of measuring ER176 in brain that requires sampling arterial blood during the scan. The investigators will compare these results to those obtained using novel methods that don't require blood sampling. The investigators hope to show that ER176 is a useful tool for measuring inflammation in Alzheimer's disease, and that the investigators can develop a way to obtain ER176 PET scans that don't require arterial blood sampling.
This study uses a special type of scan called a PET scan to take pictures of the brain. During the PET scan, a special dye is injected into the body. Two types of dye will be used in this study: Florbetaben and 11C-ER176. Florbetaben sticks to amyloid plaques, which are in the brain in Alzheimer's disease. Florbetaben has been approved by the Food and Drug Administration to help diagnose Alzheimer's disease. 11C-ER176 sticks to parts of the brain where there is inflammation. Past studies have shown that inflammation is present in the brains of patients with Alzheimer's disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 50 and older
- •Meet criteria for either a) amnestic mild cognitive impairment or Alzheimer's disease, or b) have no cognitive impairment
- •If you are unable to provide informed consent, you must have a surrogate decision maker and be able to verbally assent to the study procedures
- •Written and oral fluency in English
- •Able to participate in all scheduled evaluations and to complete all required tests and procedures.
- •In the opinion of the investigator, you must be considered likely to comply with the study protocol and to have a high probability of completing the study.
排除标准
- •Past or present history of certain brain disorders other than MCI or AD.
- •Certain significant medical conditions, which make study procedures of the current study unsafe. Such serious medical conditions include uncontrolled epilepsy and multiple serious injuries.
- •Contraindication to MRI scanning
- •Conditions precluding entry into the scanners (e.g. morbid obesity, claustrophobia, etc.).
- •Exposure to research related radiation in the past year that, when combined with this study, would place you above the allowable limits.
- •Participation in the last year in a clinical trial for a disease modifying drug for AD.
- •Inability to have a catheter in your vein for the injection of radioligand.
- •Inability to have blood drawn from your veins.
- •Taking anticoagulant medication (e.g., warfarin).
研究组 & 干预措施
Cognitive impairment
Alzheimer's disease (mild cognitive impairment or mild stage Alzheimer's disease dementia)
干预措施: 11C-ER176 (Drug)
Cognitive impairment
Alzheimer's disease (mild cognitive impairment or mild stage Alzheimer's disease dementia)
干预措施: Florbetaben (Drug)
No cognitive impairment
Healthy Controls
干预措施: 11C-ER176 (Drug)
No cognitive impairment
Healthy Controls
干预措施: Florbetaben (Drug)
结局指标
主要结局
11C-ER176 Total Distribution Volume
时间窗: Up to one year from baseline
Total distribution volume reflects the amount of TSPO (the inflammatory protein that 11C-ER176 sticks to) in the brain. This measure requires arterial blood sampling.
次要结局
- 11C-ER176 Standardized Uptake Value Ratio(Up to one year from baseline)
研究者
Patrick Lao
Assistant Professor of Neurological Sciences
Columbia University