The Effects of Epidural Anesthesia on the Bioavailability of Nitric Oxide and Renal Function in Patients Undergoing Laparoscopic Surgery

Not Applicable

Completed

• Conditions: Prostate Cancer
• Interventions: Procedure: Epidural anesthesia

• Registration Number: NCT01325844
• Lead Sponsor: Yonsei University

Brief Summary

This study was designed to investigate the effects of epidural anesthesia combined with general anesthesia during laparoscopic surgery. The investigators hypothesized that epidural anesthesia will effectively block the activation of the sympathetic nervous system during surgery, thus activating nitric oxide and reducing splanchnic ischemia and decrease in postoperative renal function.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-11
• Study First Submitted: 2011-03-28
• Study First Submitted QC: 2011-03-29
• Study First Posted: 2011-03-30
• Primary Completion: 2011-10
• Study Completion: 2011-10
• Status Verified: 2012-02
• Last Update Submitted: 2012-02-02
• Last Update Posted: 2012-02-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 45

Inclusion Criteria

• ASA class 1 or 2 adult patients scheduled for endoscopic prostatectomy

Exclusion Criteria

• Patient refusal
• Patients on diuretics
• Patients with renal failure (eGFR < 60 ml/min/1.73 m2)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
G+E group	Epidural anesthesia	G+E group = General anesthesia + epidural anesthesia group

Primary Outcome Measures

Name	Time	Method
blood pressure with heart rate variability	10 minutes after anesthesia induction

Trial Locations

Locations (1)

Severance Hospital; 🇰🇷 Seoul, Korea, Republic of