Inflammation in Vascular Disease
- Conditions
- AtherosclerosisVascular Diseases
- Registration Number
- NCT03732612
- Lead Sponsor
- Göteborg University
- Brief Summary
Increasing evidence suggests that systemic low-grade inflammation may be a driving force of cardiometabolic complications, such as vascular dysfunction, atherosclerosis and ischemic heart disease. Thus, we will investigate the role of inflammation in cardiovascular disease.
- Detailed Description
Vascular reconstruction surgeries usually require a small piece of the vessel wall to be excised. The excised vessel is generally discarded as medical waste: however, for patients participating in the study, the excised tissue will be placed in saline and collected for research use.
Tissue collected from individuals undergoing vascular surgery associated with peripheral arterial diseases, aneurysm and/or other manifestations of atherosclerosis, vascular tissue will be cultured ex vivo in the presence or absence of therapeutic agents, to determine if these attenuate the inflammation associated with the atherosclerotic phenotype. Furthermore, the protocol will also be carried out using vascular tissue from control patients, which have undergone vascular surgery that is not associated with vascular disease (e.g. knee replacement surgery, trauma, etc).
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 170
- Patient is planned to undergo vascular surgery.
- Signed informed consent has been obtained from the patient.
- Patient has difficulty to understand information.
- Patients under 18 years of age.
- Patients participating in any drug-related study.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Inflammatory status 2019-2024 The inflammatory status will be studied in patients with atherosclerotic disease.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Gothenburg
🇸🇪Gothenburg, Vastragotaland, Sweden