Physical activity, immune function and inflammation in kidney patients - a pilot study

Not Applicable

Completed

• Conditions: Chronic kidney disease; Urological and Genital Diseases

• Registration Number: ISRCTN38935454
• Lead Sponsor: niversity Hospitals of Leicester

Brief Summary

2017 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/28554920 protocol 2018 Other publications in https://pubmed.ncbi.nlm.nih.gov/29961156/ Sub-study results (added 15/02/2023) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/31736354/ (added 15/02/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-01-22
• Study Completion: 2020-09-01
• Last Update Posted: 27 February 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

1. Kidney patients of both genders aged 18 or over, with established chronic kidney disease including those on renal replacement therapy or with a transplant
2. Matched healthy controls

Exclusion Criteria

1. Aged under 18 years
2. Pregnancy
3. Received kidney transplant less than 6 months prior to study entry
4. Any element of study assessment protocol considered by own clinician to be contraindicated due to physical impairment, co-morbidity or any other reason
5. Inability to give informed consent for any reason
6. Visual or hearing impairment or insufficient command of English to give informed consent or comply with the assessment protocol

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Blood samples will be analysed for:<br> 1. Markers of metabolism, cardiovascular risk, inflammation, oxidative stress, endothelial activation and immune function in plasma serum<br> 2. Analysis of immune and inflammatory cell populations by flow cytometry<br> 3. Expression of mRNA by RT-PCR<br><br> These will be measured from blood samples taken pre exercise, 5-10 minutes post exercise and 60 minutes post exercise.<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. Anthropometric measures (height, weight, hip circumference)<br> 2. Body composition by bioelectrical impedance analysis<br> 3. Cardiac bioreactance by NICOM (non-invasive cardiac output monitoring)<br> 4. Time spent in leisure activities (Leisure Time Exercise Questionnaire)<br><br> These measures will be made once during the familiarisation visit (Visit 1). Clinical information will be obtained from medical records .<br>