The Effects of Perioperative Dexmedetomidine Infusion on Hemodynamic Stability During Laparoscopic Adrenalectomy for Pheochromocytoma: a Randomized Study
Overview
- Phase
- Not Applicable
- Intervention
- dexmedetomidine
- Conditions
- Pheochromocytoma
- Sponsor
- Yonsei University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Intraoperative hemodynamic stability (duration of SBP exceeding 200 mmHg)
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The investigators planned this study to investigate the effects of dexmedetomidine administration on intraoperative hemodynamic stability in patients with pheochromocytoma.
Investigators
Eligibility Criteria
Inclusion Criteria
- •ages of 20 and 70
- •American Society of Anesthesiologists(ASA) physical status classification I to III,
- •planned laparoscopic adrenalectomy for pheochromocytoma.
Exclusion Criteria
- •emergency operation,
- •re-operation,
- •combined surgery with other departments,
- •body mass index (BMI) \>32 kg/m2,
- •history of arrhythmias (especially AV nodal block) and ventricular conduction abnormalities,
- •uncontrolled hypertension (diastolic blood pressure \>110mmHg)
- •bradycardia (heart rate \< 40 beats per minute),
- •history of heart failure, hepatic and/or renal failure,
- •history of cerebrovascular disease (cerebral hemorrhage, cerebral ischemia),
- •history of beta-blocker therapy, 10) history of uncontrolled psychiatric disease.
Arms & Interventions
dexmedetomidine group
In the dexmedetomidine group, dexmedetomidine is administered at a rate of 0.5 μg/kg/h immediately after anesthesia induction and continued until the completion of the surgery.
Intervention: dexmedetomidine
Control group
In the control group, a 0.9% normal saline infusion is initiated at the same rate immediately after anesthesia induction and continued until the end of the operation.
Intervention: 0.9% normal saline
Outcomes
Primary Outcomes
Intraoperative hemodynamic stability (duration of SBP exceeding 200 mmHg)
Time Frame: during operation
Intraoperative hemodynamic stability (duration of SBP increase by 30% or more from baseline (in minutes)
Time Frame: during operation
Intraoperative hemodynamic stability ( maximum blood pressure during surgery (systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP))
Time Frame: during operation
Intraoperative hemodynamic stability (maximum HR during surgery)
Time Frame: during operation
Intraoperative hemodynamic stability (duration of HR exceeding 110 beats per minute during surgery)
Time Frame: during operation
Intraoperative hemodynamic stability (comparison of the quantity of vasoactive drugs (nitroprusside, esmolol, norepinephrine) used during surgery)
Time Frame: during operation
Secondary Outcomes
- levels of catecholamines(immediately after the completion of surgery)