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Clinical Trials/NCT05160870
NCT05160870
Recruiting
Not Applicable

Genotype-phenotype Correlation and Pathogenic Mechanism in Hereditary Ataxia

Second Affiliated Hospital, School of Medicine, Zhejiang University1 site in 1 country500 target enrollmentJune 30, 2021
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ConditionsHereditary Ataxia

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Hereditary Ataxia
Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Enrollment
500
Locations
1
Primary Endpoint
Serum neurofilament light chain
Status
Recruiting
Last Updated
4 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

The investigators aimed to find appropriate biomarkers such as serum neurofilament light chain in reflecting disease severity in hereditary ataxia from a large cohort during long-term follow-up. The disease severity is indicated by clinical scales and brain MRI tests.

Registry
clinicaltrials.gov
Start Date
June 30, 2021
End Date
December 25, 2025
Last Updated
4 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •genetically diagnosed as Spinocerebellar ataxia

Exclusion Criteria

  • •deny follow-yp

Outcomes

Primary Outcomes

Serum neurofilament light chain

Time Frame: from 2021 to 2025

Serum neurofilament light chain levels were collected among patients in preclinical or mild stage of Spinocerebellar ataxia, especially type 3.

Study Sites (1)

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