Better Understand Motor Deficits Associated With Autism Spectrum Disorders: Development of an Assessment Protocol

Not Applicable

Recruiting

• Conditions: Autism Spectrum Disorder
• Interventions: Behavioral: Testing of general motor skills, fine motor skills and occulomotricity; Behavioral: Questionnaires

• Registration Number: NCT05236803
• Lead Sponsor: Centre Hospitalier Charles Perrens, Bordeaux

Brief Summary

This research is a case-control study aiming to characterize motor peculiarities (objective quantitative and qualitative measures) and its psycho-physiological correlates of children with ASD.

Detailed Description

The main objective is to measure jointly and in an automated and standardized manner the performance and motor patterns within the framework of tasks measuring the performance and patterns of general motor skills (postures, walking, coordination overall), fine motor skills (graphics, pointing task) and oculomotricity (visual orientation and control).

The secondary objective is to investigate the relationships between motor difficulties and cognitive and social disorders found in children with ASD.

* Compare the motor performance data in the 3 major motor domains with each other (overall, fine and oculomotor);

* Evaluate intergroup differences based on clinical characteristics (ADOS-2, ADI-R, CARS 2 scores), age, IQ, socio-communication profile score (SRS-2) and presence comorbidities (TADH, TDC).

Study Timeline

• Study First Submitted: 2021-12-15
• Study First Submitted QC: 2022-02-02
• Study Start: 2022-02-07
• Study First Posted: 2022-02-11
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-17
• Last Update Posted: 2024-06-18
• Primary Completion: 2025-01-31
• Study Completion: 2025-03-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Epidemiology	Testing of general motor skills, fine motor skills and occulomotricity	Recording of participant's performance during eye, fine motor and gross motor tests Passing self and hetero questionnaires.
Epidemiology	Questionnaires	Recording of participant's performance during eye, fine motor and gross motor tests Passing self and hetero questionnaires.

Primary Outcome Measures

Name	Time	Method
Measurement of oculomotricity with eye-tracking system (visual orientation and control)	At 3 month	Jointly and in an automated and standardized manner, motor patterns in the context of tasks measuring the performance and patterns of general motor skills (postures, walking, overall coordination), fine motor skills (graphics, pointing task) and oculomotricity (visual orientation and control).
Measurement performance of fine motor skills (graphics, pointing task)	At 3 month	Jointly and in an automated and standardized manner, measure performance in the context of tasks measuring the performance and patterns of general motor skills (postures, walking, overall coordination), fine motor skills (graphics, pointing task) and oculomotricity (visual orientation and control).
Measurement performance of general motor skills with biomechanical analysis	At 3 month	Jointly and in an automated and standardized manner, measure motor patterns in the context of tasks measuring the performance and patterns of general motor skills (postures, walking, overall coordination), fine motor skills (graphics, pointing task) and oculomotricity (visual orientation and control).

Secondary Outcome Measures

Name	Time	Method
Score of socio-communicative skills as assessed using Social Responsiveness Scale	At visit 1 and visit 2, an average of 3 months	Social Responsiveness Scale : Min = 30, Max=90 Higher scores mean a worse outcome
Motor performance : success, error rate (%)	At visit 1 and visit 2, an average of 3 months
Motor performance : task duration (ms), reaction time (ms) and latency (ms)	At visit 1 and visit 2, an average of 3 months
IQ as assessed using WISC IV	At visit 1 and visit 2, an average of 3 months
ADHD as assessed using Conners-3	At visit 1 and visit 2, an average of 3 months
Developmental Coordination Disorder as assessed using Developmental Coordination Disorder Questionnaire	At visit 1 and visit 2, an average of 3 months	Developmental Coordination Disorder Questionnaire : Min = 15, Max = 75 Higher scores mean a better outcome
ASD Clinical Assessment as assessed using Childhood Autism Rating Scale	At visit 1 and visit 2, an average of 3 months	Childhood Autism Rating Scale : Min = 0, Max = 100 Higher scores mean a worse outcome

Trial Locations

Locations (4)

Centre Hospitalier Henri Laborit; 🇫🇷 Poitiers, France

Centre Hospitalier Charles Perrens; 🇫🇷 Bordeaux, France

CHU de LIMOGES; 🇫🇷 Limoges, France

Centre Hospitalier La Rochelle Re Aunis; 🇫🇷 La Rochelle, France