Impact of COVID-19 Pandemic on Early Spontaneous Abortions and Early Termination of Pregnancy

Completed

• Conditions: Termination of Pregnancy; Covid19; Pregnancy Loss

• Registration Number: NCT04910958
• Lead Sponsor: Hillel Yaffe Medical Center

Brief Summary

To see the impact the COVID-19 pandemic has had on early spontaneous abortions and early termination of pregnancy in the first trimester

Detailed Description

To date, the research has focused on the complications of SARS-CoV-2 in pregnant women. There is no research in the literature that has compared the rates and behavior of miscarriage during the time of the COVID-19 pandemic to before the time of the pandemic. As described in the literature, there is an established connection between COVID-19 and stress, anxiety, and depression. There is also an established connection between stress, anxiety, and depression and rates of miscarriage. The investigators hereby wish to analyze the effect of the COVID-19 pandemic on miscarriages.

In this study, The investigators will analyze the number of early missed abortions and number of termination of pregnancies in the first trimester before and during the COVID-19 pandemic. The investigators will also analyze the time interval between diagnosis of missed abortion and attendance to E.R in missed abortions during the COVID-19 pandemic. In addition, The investigators will be comparing the reasons for termination of pregnancy during this time, as well as analyzing age, religion, and demographic variables during the COVID-19 pandemic compared to years prior.

Study Timeline

• Study Start: 2021-01-06
• Study First Submitted: 2021-06-01
• Study First Submitted QC: 2021-06-01
• Study First Posted: 2021-06-02
• Primary Completion: 2022-08-09
• Study Completion: 2022-08-09
• Status Verified: 2022-12
• Last Update Submitted: 2022-12-05
• Last Update Posted: 2022-12-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 411

Inclusion Criteria

• All women attending for early missed abortion or termination of pregnancy receiving treatment between March 11th - November 30th during the years 2017-2020 Gestational age until 12 weeks 6 days (1st trimester only)

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Exclusion Criteria

• Incomplete and complete abortions
• Gestational age >13 weeks

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of termination of pregnancies	Two years	Number of termination of pregnancies in the first trimester in COVID19 time compared to years prior
Number of early missed abortions	Two years	Number of early missed abortions in the first trimester in COVID19 time compared to years prior

Secondary Outcome Measures

Name	Time	Method
Comparison of reasons for termination	1 year	Comparison of reasons for termination of pregnancy during COVID19 time compared to years prior
Comparison of Age/Religion/Demographic variables	1 year	Comparison of Age/Religion/Demographic variables of termination of pregnancy during COVID19 time compared to years prior
Time between discovery and attendance	1 year	Time between discovery and attendance in missed abortions during COVID19 time compared to years prior

Trial Locations

Locations (1)

Hillel Yaffe Medical Center; 🇮🇱 Hadera, Israel