Precision in Severe Pneumonia Management (PRISM)

Community-acquired pneumonia (CAP) remains a significant cause of ICU admissions worldwide, with viruses contributing substantially to the disease burden. Coinfections with bacteria and viruses further complicate the course and outcomes of patients with viral pneumonia. Pathogen detection rates—and consequently the effectiveness of our empiric regimens, especially concerning drug resistance—remain uncertain. The advent of multiplex PCR techniques with antimicrobial resistance gene detection offers a promising alternative. While these methods provide quicker results and greater sensitivity than conventional techniques, their impact on pragmatic, patient-centered outcomes is still unclear. Evaluating the utility of novel multiplex PCR for pathogen and resistance gene detection within the Indian population is essential. This study aims to determine whether multiplex PCR for severe pneumonia can improve clinical outcomes in our setting.