ISRCTN85372848已完成未知
A randomised controlled trial of high-dose immunosuppression in paraquat poisoning
South Asian Clinical Toxicology Research Collaboration (SACTRC) (Sri Lanka)0 个研究点目标入组 299 人开始时间: 2006年8月1日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 299
研究概览
简要总结
2018 results in https://pubmed.ncbi.nlm.nih.gov/29098875/ (added 01/07/2021)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Patients with a history of acute paraquat poisoning
- •2. Presenting within 24 hours of paraquat ingestion with evidence of paraquat intoxication by urinary dithionite test
排除标准
- •1. Under 14 years
- •2. Pregnant
- •3. Systolic blood pressure of less than 70 mmHg, unresponsive to one litre fluid challenge, Glasgow Coma Score (GCS) less than 8/15, or cyanosis
- •4. Already received cyclophosphamide or methylprednisolone for this episode of poisoning
- •5. Allergic to cyclophosphamide, methylprednisolone, dexamethasone or mesna
- •6. Unable to give consent, or not accompanied by a relative, where the hospital consultant prefers that consent be obtained from a relative rather than the consultant looking after the patient
- •7. Present more than 24 hours after paraquat ingestion
研究者
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