Thiamin Deficiency in Obese Thai Children
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 124
- 试验地点
- 1
- 主要终点
- abnormal thiamin pyrophosphate effect
研究概览
简要总结
This study is aimed to assess the prevalence of thiamin deficiency in obese Thai children.
详细描述
This study is a cross-sectional study. The objectives of the study are to determine the prevalence of thiamin deficiency in obese Thai children and to assess the associations of dietary factors and thiamin deficiency.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 7 Years 至 15 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •obese : weight for height > median + 3 standard deviations
- •simple obesity
排除标准
- •pathological obesity
- •chronic diseases e.g. cerebral palsy, metabolic disease, etc.
- •diseases of red blood cells
- •on medication e.g. steroid, multivitamins, thiamine-containing vitamins, diuretic drugs
- •hemodialysis or peritoneal dialysis
- •bariatric surgery
研究组 & 干预措施
Thiamine 1
presence of severe symptoms and signs of thiamine deficiency: heart failure, convulsion, coma, loss of ankle and knee jerks with muscular wasting and paralysis (typically symmetrical foot- and wrist-drop)
干预措施: Thiamine 1 (Drug)
Non-thiamine
no symptoms and signs of thiamine deficiency
干预措施: Non-thiamine (Other)
Thiamine 2
presence of mild symptoms and signs of thiamine deficiency; peripheral neuropathy alone (paraesthesia of hands and feet)
干预措施: Thiamine 2 (Drug)
结局指标
主要结局
abnormal thiamin pyrophosphate effect
时间窗: 7 days
Thiamin pyrophosphate effect will be measured by a blood test
次要结局
- consumption of thiaminase-containing foods and thiamin antagonist-containing foods(7 days)