A Micro/Nano Device for Exhaled Breath Analysis
Completed
- Conditions
- Lung CancerPulmonary Disease
- Registration Number
- NCT02123030
- Lead Sponsor
- University of Louisville
- Brief Summary
Use of a microfabricated silicon device to concentrate ultra trace volatile organic compounds (VOCs) in human exhaled breath for quantitative analysis of VOCs.
- Detailed Description
Will use Fourier Transform Mass Spectrometry (FT-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) to analyze concentrated VOCs. The purpose of this study is to search for disease-related markers in the breath in subjects with known or suspected lung or other cancer, or pulmonary disease.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 728
Inclusion Criteria
- For controlled (healthy) subjects - we are seeking persons who do not have a known history of cancer or pulmonary disease.
- Both smokers and nonsmokers are invited to participate as control subjects.
- For experimental subjects, we are seeking persons with pulmonary disease but no known history of cancer, as identified by the investigators during routine clinic or office visits.
- Additionally for experimental subjects, we are seeking persons with known or suspected lung or other cancers, as identified by the investigators during routine clinic or office visits.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Detection of disease related markers (biomarkers) from concentrated volatile organic compounds in breath samples 1 day (After sample collection) The concentrated volatile organic compounds in exhaled breath samples will be analyzed by statistical software for search for disease related markers (biomarkers).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
James Graham Brown Cancer Center-University of Louisville
🇺🇸Louisville, Kentucky, United States