Efficacy of Viscosupplementation Associated With Intra-articular Corticosteroid Injection Versus Intra-articular Injection of Corticosteroids Alone in Osteoarthritis of Hip
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Hip Osteoarthritis
- Sponsor
- CHU de Reims
- Enrollment
- 43
- Locations
- 1
- Primary Endpoint
- improving pain
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The current management of osteoarthritis is based on non-pharmacological and pharmacological means which include intra-articular injections.
The recommendations on the management of hip osteoarthritis stipulate that intra-articular injections of corticosteroid may be considered in patients with an exacerbation not responding to oral treatments. Several recent studies show the effectiveness of intra-articular corticosteroids compared with anesthetics. The intra-articular injection of viscosupplementation alone has never been validated in this indication since controlled studies did not show efficacy over placebo. At present, viscosupplementation is considered an anti-osteoarthritic symptomatic slow-acting and its interest is not yet established in hip osteoarthritis.
Detailed Description
Show the superiority of intra-articular injection of viscosupplementation in combination with corticosteroid compared to intra-articular injection of corticosteroid alone in the treatment of hip osteoarthritis.
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients with hip osteoarthrosis (stage II et III according Kellgren et Lawrence)
- •walking alone patients
- •patient consenting to participate to the study
- •patient enrolled in the national healthcare insurance program
- •patient older than 18 years
Exclusion Criteria
- •Patients with hip osteoarthrosis (stage I et IV according Kellgren et Lawrence)
- •patients with rapidly destructive hip osteoarthritis
- •patients with inflammatory rheumatism
- •patients with microcrystalline arthritis
- •patients with hip osteonecrosis
- •patients who received corticosteroids during the previous three months
- •patients who received a intra articular injection of viscosupplementation during the previous six months
- •patient with haemostatic disorder
- •patient with consumption of painkillers tier 3
Outcomes
Primary Outcomes
improving pain
Time Frame: 3 months
decrease of 20 mm on a visual analog pain scale between the evaluation at day 0 and the evaluation at 3 months