Investigation of Genetic Risk of Cardiovascular Disease in Prospective Cohort Study

• Conditions: Healthy; Coronary Disease; Myocardial Infarction; Cerebral Infarction

• Registration Number: NCT00262691
• Lead Sponsor: Nagoya University

Brief Summary

Cardiovascular disease is a complex multifactorial and polygenic disorder that is thought to result from an interaction between a person's genetic make up and various environmental factors. Although many studies have revealed that several genetic variants increase the risk of cardiovascular disease, the results of these studies remain controversial. The purpose of this study is to identify polymorphisms that confer susceptibility to cardiovascular disease and to clarify the adequacy of reported susceptibility gene polymorphisms. To complete this purpose, we will prospectively study over 5,000 local residents in whom relationship between these polymorphisms and occurrence of cardiovascular disease over 5 years.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-05
• Study First Submitted: 2005-12-06
• Study First Submitted QC: 2005-12-06
• Study First Posted: 2005-12-07
• Status Verified: 2007-09
• Last Update Submitted: 2007-09-20
• Last Update Posted: 2007-09-21

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 7000

Inclusion Criteria

• Healthy subjects who undergo community-based annual health check in Kitanagoya city

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Department of Genome Science, School of Dentistry, Aichi-Gakuin University; 🇯🇵 Nagoya, Aichi, Japan