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临床试验/NCT07267767
NCT07267767已完成不适用

Comparison of Six Different Machine Learning Methods With Traditional Model for Low Anterior Resection Syndrome After Minimally Invasive Surgery for Rectal Cancer -- Development and External Validation of a Nomogram : A Dual-center Cohort Study

Northern Jiangsu People's Hospital0 个研究点目标入组 3,500 人开始时间: 2015年4月10日最近更新:

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
3,500
主要终点
low anterior resection syndrome

研究概览

简要总结

Following thorough screening based on inclusion and exclusion criteria, patients from the two sizable medical centers were split up into two cohorts for this study. Cohort 1 served primarily as the training and internal validation set, while Cohort 2 was used for external validation of the predictive model constructed from Cohort 1. We used six distinct machine learning methodss, including DT, RF, XGBOOST, SVM, lightGBM, and SHLNN, in addition to conventional logistic regression to create the predictive model. We chose the approach with the best sensitivity and specificity by comparing the concordance index(C-index) akin to the area under the ROC curve (AUC) of these seven distinct model-building methods. The predictive model for Cohort 1 was then built using this method, and internal validation was finished. Lastly, Cohort 2 underwent external validation of the predictive model

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Cross Sectional

入排标准

性别
All
接受健康志愿者

入选标准

  • (1) rectal adenocarcinoma (2) minimally invasive sphincter-preserving surgery (taTME/ISR/LAR) (3) intact baseline anal function (4) no emergent presentations or metastases.

排除标准

  • emergent presentations or metastases

结局指标

主要结局

low anterior resection syndrome

时间窗: 1 and 3 months after surgery

Comparison of Six Different Machine Learning Methods With Traditional Model for Low Anterior Resection Syndrome After Minimally Invasive Surgery for Rectal Cancer -- Development and External Validation of a Nomogram : A Dual-center Cohort Study

时间窗: 3 months

using LARS Score to assess the LARS situation

次要结局

未报告次要终点

研究者

发起方
Northern Jiangsu People's Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Daorong Wang

NANJING UNIVERSITY

Northern Jiangsu People's Hospital

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