Feasibility of Combined Genomics/Transcriptomics for Patients With Lymphoma

Not Applicable

Recruiting

• Conditions: Lymphoma
• Interventions: Other: Molecular Functional Portrait

• Registration Number: NCT05464823
• Lead Sponsor: M.D. Anderson Cancer Center

Brief Summary

To learn more about the usefulness of molecular testing with the Molecular Functional (MF) Portrait (a commercial test conducted by the sponsor of this study, BostonGene) in guiding lymphoma care.

Detailed Description

Primary Objective:

• To determine the feasibility and turnaround of clinical WES and transcriptome sequencing

Secondary Objectives:

* To determine the frequency of actionable DNA and RNA alterations

* To determine the concordance of DNA and RNA alterations

* To determine the frequency of molecularly matched therapy

* To determine the feasibility of identifying mechanism(s) of acquired resistance with genomic profiling

* To determine the feasibility of molecularly matched therapy to acquired resistance alterations

Exploratory Objectives:

* To determine the feasibility of prioritizing targets with precision analytics

* To determine clinical outcomes in patients receiving molecularly matched therapy

* To determine the role of additional emerging diagnostic technologies

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2022-07-07
• Study First Submitted: 2022-07-12
• Study First Submitted QC: 2022-07-14
• Study First Posted: 2022-07-19
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-15
• Last Update Posted: 2024-08-16
• Primary Completion: 2027-05-12
• Study Completion: 2027-05-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Male/female patients who are at least 18 years of age on the day of informed consent signing.
2. Patients must have a histologically documented diffuse large B-cell lymphoma requiring therapy.
3. Provision of written informed consent for the study.

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Exclusion Criteria

1. None

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Molecular Testing	Molecular Functional Portrait	Molecular Functional (MF) Portrait (a commercial test conducted by the sponsor of this study, BostonGene) in guiding lymphoma care.

Primary Outcome Measures

Name	Time	Method
Percentage of participants who have genomic test results available in <=7 days	through study completion an average of 1 year

Trial Locations

Locations (1)

M D Anderson Cancer Center; 🇺🇸 Houston, Texas, United States