Motor Imagery for Reach-to-grasp Rehabilitation After Tetraplegia

Not Applicable

Completed

• Conditions: Tetraplegia C5-C6; Tetraplegia C6-C7
• Interventions: Procedure: motor imagery

• Registration Number: NCT02860403
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Single center, pilot study, to evaluate the influence of Motor Imagery (MI) on functional rehabilitation and cerebral plasticity through the qualitative and quantitative mental practice approach. For this, the investigators will use magnetoencephalography (MEG) but also physiological and behavioral indicators developed by the Laboratoire de la Performance Motrice, Mentale et du Matériel (P3M) of Université Claude Bernard Lyon 1 and its partners.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-02
• Primary Completion: 2013-03
• Study Completion: 2013-03
• Status Verified: 2016-08
• Study First Submitted: 2016-08-04
• Study First Submitted QC: 2016-08-08
• Study First Posted: 2016-08-09
• Last Update Submitted: 2019-05-23
• Last Update Posted: 2019-05-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• 18-55 years old,
• quadriplegia elicited by spinal cord injury (SCI) at the C5, C5-C6, C6, or C6-C7 level,
• complete infra-lesional motor deficit according to the ASIA impairment scale with finger and forearm flexor muscles paralysis,
• post-traumatic period >6 months (since a motor recovery plateau is usually reached at 6-month post-SCI

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Exclusion Criteria

• non-stabilized hypertension or pathological autonomic nervous system dysfunction (e.g., orthostatic hypotension),
• cerebral damage and/or cognitive deficit,
• elbow or shoulder joint amplitude restriction, upper limb para-osteoarthropathy,
• participation to another study
• presence of metallic objects within the body incompatible with MEG or functional magnetic resonance imaging (fMRI) recordings.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
C6-C7 patients	motor imagery	C6-C7 patients able to recover tenodesis grasp.
C5-C6 patients	motor imagery	C5-C6 patients for whom surgery for rehabilitation of an upper limb is indicated with a upper limit of one year after trauma, and after complete clinical and functional evaluation

Primary Outcome Measures

Name	Time	Method
Motor imagery ability	10 weeks	Motor imagery ability assessed by magnetoencephalography measurements

Secondary Outcome Measures

Name	Time	Method
time to maximal opening	10 weeks	Kinematic parameters of movement: temporal parameters: time to maximal opening
Trajectory of movement measured in the XY plane	10 weeks	Kinematic parameters of movement: spatial parameters: Trajectory of movement measured in the XY plane
joint amplitude evaluated in degrees (°) by the physiotherapist	10 weeks
muscular force evaluated by muscle testing performed by a physiotherapist	10 weeks	muscular force evaluated by muscle testing performed by a physiotherapist (score from 0 to 5)
Box and Block test	10 weeks	Box and Block test performed by an occupational therapist
absolute time to peak velocity	10 weeks	Kinematic parameters of movement: temporal parameters: absolute time to peak velocity
amplitude of electrodermal responses	10 weeks	mental chronometric assessment associated with acquisition of electrodermal responses
duration of electrodermal responses	10 weeks	mental chronometric assessment associated with acquisition of electrodermal responses
Movement time (MT)	10 weeks	Kinematic parameters of movement: temporal parameters: movement time (MT)
movement amplitude at peak velocity	10 weeks	Kinematic parameters of movement: temporal parameters: movement amplitude at peak velocity
time to opening	10 weeks	Kinematic parameters of movement: temporal parameters: time to opening
height of elbow and wrist at the moment of grasping an object, measured in mm in the YZ plane	10 weeks	Kinematic parameters of movement: spatial parameters: height of elbow and wrist at the moment of grasping an object, measured in mm in the YZ plane
Kinesthetic and Visual Imagery Questionnaire	10 weeks	The Kinesthetic and Visual Imagery Questionnaire (KVIQ) will allow a qualitative evaluation of the mental representation capacity of patients
amplitude of maximal opening	10 weeks	Kinematic parameters of movement: temporal parameters: amplitude of maximal opening
Minnesota test.	10 weeks	Minnesota test performed by an occupational therapist

Trial Locations

Locations (1)

Hôpital Henry Gabrielle - Médecine physique et Réadaptation, Hospices Civils de Lyon, 20 Route de Vourles,; 🇫🇷 Saint-Genis-Laval, France