Motor Imagery for Reach-to-grasp Rehabilitation After Tetraplegia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Motor imagery ability
研究概览
简要总结
Single center, pilot study, to evaluate the influence of Motor Imagery (MI) on functional rehabilitation and cerebral plasticity through the qualitative and quantitative mental practice approach. For this, the investigators will use magnetoencephalography (MEG) but also physiological and behavioral indicators developed by the Laboratoire de la Performance Motrice, Mentale et du Matériel (P3M) of Université Claude Bernard Lyon 1 and its partners.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-55 years old,
- •quadriplegia elicited by spinal cord injury (SCI) at the C5, C5-C6, C6, or C6-C7 level,
- •complete infra-lesional motor deficit according to the ASIA impairment scale with finger and forearm flexor muscles paralysis,
- •post-traumatic period >6 months (since a motor recovery plateau is usually reached at 6-month post-SCI
排除标准
- •non-stabilized hypertension or pathological autonomic nervous system dysfunction (e.g., orthostatic hypotension),
- •cerebral damage and/or cognitive deficit,
- •elbow or shoulder joint amplitude restriction, upper limb para-osteoarthropathy,
- •participation to another study
- •presence of metallic objects within the body incompatible with MEG or functional magnetic resonance imaging (fMRI) recordings.
研究组 & 干预措施
C6-C7 patients
C6-C7 patients able to recover tenodesis grasp.
干预措施: motor imagery (Procedure)
C5-C6 patients
C5-C6 patients for whom surgery for rehabilitation of an upper limb is indicated with a upper limit of one year after trauma, and after complete clinical and functional evaluation
干预措施: motor imagery (Procedure)
Control group
a control group (n=6) matched on age and sex to C6-C7 without medical history or neurological disorder
结局指标
主要结局
Motor imagery ability
时间窗: 10 weeks
Motor imagery ability assessed by magnetoencephalography measurements
次要结局
- time to maximal opening(10 weeks)
- Trajectory of movement measured in the XY plane(10 weeks)
- joint amplitude evaluated in degrees (°) by the physiotherapist(10 weeks)
- muscular force evaluated by muscle testing performed by a physiotherapist(10 weeks)
- Box and Block test(10 weeks)
- amplitude of electrodermal responses(10 weeks)
- absolute time to peak velocity(10 weeks)
- duration of electrodermal responses(10 weeks)
- Movement time (MT)(10 weeks)
- movement amplitude at peak velocity(10 weeks)
- time to opening(10 weeks)
- height of elbow and wrist at the moment of grasping an object, measured in mm in the YZ plane(10 weeks)
- Kinesthetic and Visual Imagery Questionnaire(10 weeks)
- amplitude of maximal opening(10 weeks)
- Minnesota test.(10 weeks)