NCT00612625已完成不适用
Near Normalisation of Blood Glucose Improves the Potentiating Effect of GLP-1 on Glucose Induced Insulin Secretion in Patients With Type 2 Diabetes
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- insulin secretion rate (ISR) were derived by deconvolution of c-peptide. ISR is expressed as pmol/kg/min
研究概览
简要总结
The ability of glucagon-like peptide 1 to enhance beta-cell responsiveness to I.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near-normalisation og blood glucose improves the potentiation of glucose-stimulated insulin secretion by GLP-1
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-70 years
- •Type 2 diabetes diagnosed after 30 years of age
- •BMI > 25
排除标准
- •Severe complications to diabetes
- •Abnormal liver og kidney function
- •Haemoglobin below the lower limit
- •Macroalbuminuria
- •Systemic disease
- •Pregnancy
研究组 & 干预措施
GLP-1
Experimental
A graded glucose infusion with an infusion of GLP-1 (1½ pmol/kg/min)
干预措施: glucagon-like peptide-1 (Drug)
Saline
Experimental
A graded glucose infusion together with a continuous infusion of saline
干预措施: Saline (Drug)
结局指标
主要结局
insulin secretion rate (ISR) were derived by deconvolution of c-peptide. ISR is expressed as pmol/kg/min
时间窗: 180 minutes
次要结局
- The calculated ISR values was plotted against the ambient plasma glucose. The slopes of this linear relationships were calculated by cross-correlation analysis and is and estimation of beta-cell responsiveness (pmol/kg/min)/mmol/l(180 minutes)
研究者
研究点 (1)
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