ACTRN12619001274167招募中未知
A pragmatic, multi-centre, patient and assessor-blinded, parallel group, randomised controlled trial (RCT) comparing a ‘standard’ and ‘augmented’ systolic blood pressure strategy during general anaesthesia for endovascular thrombectomy in acute ischaemic stroke
Dr Douglas Campbell0 个研究点目标入组 550 人开始时间: 2019年9月16日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 550
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Adults equal to and greater than 18 years of age who fulfill all of the following inclusion criteria, none of the exclusion criteria, and have undergone an appropriate consenting process.
- •Inclusion criteria
- •Patients diagnosed with anterior circulation stroke (ICA or proximal M1 or M2 segment of MCA) treated with ECR within 6 hrs of stroke onset and ECR patients presenting within 6-24 hours and favourable penumbra on perfusion scanning (see criteria 1-3).
- •Additional criteria in the 6 to 24-hour window.
- •1. ‘wake up’ stroke; CT with no (or at most minimal) acute infarction or
- •2. patient 80 years or older (NIHSS of 10 and infarct volume less than 21 ml on DWI or CT perfusion-CBF)
- •3. patient less than 80 years (NIHSS of 10 and infarct volume less than 31 ml on DWI or CT perfusion-CBF NIHSS of 20 and infarct volume less than 51 ml on DWI or CT perfusion-CBF).
排除标准
- •Rescue”’ procedures eg acute ischaemic stroke associated with major medical procedures such as coronary artery stenting and coronary artery bypass
- •pre-stroke mRS>=3
- •not having GA
- •terminal illness with expected survival <1 year
- •cardiovascular conditions where BP targeting will be contra-indicated
- •unable to participate in 3-month follow up
研究者
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