ACTRN12619001274167
Recruiting
未知
A pragmatic, multi-centre, patient and assessor-blinded, parallel group, randomised controlled trial (RCT) comparing a ‘standard’ and ‘augmented’ systolic blood pressure strategy during general anaesthesia for endovascular thrombectomy in acute ischaemic stroke
Dr Douglas Campbell0 sites550 target enrollmentSeptember 16, 2019
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- Dr Douglas Campbell
- Enrollment
- 550
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adults equal to and greater than 18 years of age who fulfill all of the following inclusion criteria, none of the exclusion criteria, and have undergone an appropriate consenting process.
- •Inclusion criteria
- •Patients diagnosed with anterior circulation stroke (ICA or proximal M1 or M2 segment of MCA) treated with ECR within 6 hrs of stroke onset and ECR patients presenting within 6\-24 hours and favourable penumbra on perfusion scanning (see criteria 1\-3\).
- •Additional criteria in the 6 to 24\-hour window.
- •1\. ‘wake up’ stroke; CT with no (or at most minimal) acute infarction or
- •2\. patient 80 years or older (NIHSS of 10 and infarct volume less than 21 ml on DWI or CT perfusion\-CBF)
- •3\. patient less than 80 years (NIHSS of 10 and infarct volume less than 31 ml on DWI or CT perfusion\-CBF NIHSS of 20 and infarct volume less than 51 ml on DWI or CT perfusion\-CBF).
Exclusion Criteria
- •Rescue”’ procedures eg acute ischaemic stroke associated with major medical procedures such as coronary artery stenting and coronary artery bypass
- •pre\-stroke mRS\>\=3
- •not having GA
- •terminal illness with expected survival \<1 year
- •cardiovascular conditions where BP targeting will be contra\-indicated
- •unable to participate in 3\-month follow up
Outcomes
Primary Outcomes
Not specified
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