MAnagement of Systolic blood pressure during Thrombectomy by Endovascular Route for acute ischaemic STROKE: the MASTERSTROKE trial

Not Applicable

Recruiting

• Conditions: Stroke; Endovascular Thrombectomy; Stroke - Ischaemic

• Registration Number: ACTRN12619001274167
• Lead Sponsor: Dr Douglas Campbell

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-09-16
• Last Update Posted: 21 August 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 550

Inclusion Criteria

Adults equal to and greater than 18 years of age who fulfill all of the following inclusion criteria, none of the exclusion criteria, and have undergone an appropriate consenting process.

Inclusion criteria
Patients diagnosed with anterior circulation stroke (ICA or proximal M1 or M2 segment of MCA) treated with ECR within 6 hrs of stroke onset and ECR patients presenting within 6-24 hours and favourable penumbra on perfusion scanning (see criteria 1-3).
Additional criteria in the 6 to 24-hour window.
1. ‘wake up’ stroke; CT with no (or at most minimal) acute infarction or
2. patient 80 years or older (NIHSS of 10 and infarct volume less than 21 ml on DWI or CT perfusion-CBF)
3. patient less than 80 years (NIHSS of 10 and infarct volume less than 31 ml on DWI or CT perfusion-CBF NIHSS of 20 and infarct volume less than 51 ml on DWI or CT perfusion-CBF).

Exclusion Criteria

•Rescue”’ procedures eg acute ischaemic stroke associated with major medical procedures such as coronary artery stenting and coronary artery bypass
•pre-stroke mRS>=3
•not having GA
•terminal illness with expected survival <1 year
•pregnancy
•cardiovascular conditions where BP targeting will be contra-indicated
•unable to participate in 3-month follow up

Study & Design

• Study Type: Interventional
• Study Design: Not specified