Preventing muscle wasting in critically ill patients by repetitive occlusive stimulus (ROS): a feasibility study

Royal Surrey County Hospital NHS Foundation Trust0 个研究点目标入组 12 人开始时间: 2017年10月26日最近更新: 2023年12月4日

试验速览

2019 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/31340849 protocol (added 26/07/2019) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35887701/ (added 21/11/2023)

•1. Age = 18 years, both male & female
•2. Admitted to the ICU within the past 36 hours
•3. Personal consultee provides declaration of agreement for patient enrolment, retrospective patient consent
•4. Invasive mechanical ventilation
•5. At least 2 other organ failures as defined by scoring =1 points on two of the SOFA score domains
•6. Likely to remain on ICU for at least 4 days as classified by attending consultant

•1. Profound cardiovascular instability – infused vasopressors > = 0.5mcg/kg/min of norepinephrine; or in opinion of senior attending doctor
•2. Profound coagulopathy (Prothrombin time> 2.5x normal or platelet count of < 80) or bleeding diathesis
•3. Neuromuscular condition – any previous or concurrent neurological condition or muscle disease
•4. History of peripheral arterial vascular disease – any previous surgery or interventional procedure for peripheral arterial insufficiency, or any reason to clinically suspect arterial insufficiency of the leg – such as collateral history of claudication or examination findings of absent peripheral pulses
•5. Prior amputation of a lower limb
•6. Obesity (BMI> 40); due to technical considerations.
•7. Unlikely to survive ICU
•8. Disseminated malignancy
•9. Pregnancy
•10. Previous, or current, DVT and PE
•11. Positioned prone
•12. Contraindication to pharmacological venous thromboembolism prophylaxis
•13. Pre-existing significant cognitive impairment
•14. Enrolled in a conflicting interventional trial
•15. Lack ability to communicate in verbal and written English

发起方

Royal Surrey County Hospital NHS Foundation Trust