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临床试验/CTRI/2024/08/072421
CTRI/2024/08/072421尚未招募不适用

Evaluation of Arterial Blood Gas as a predictor of successful tracheal extubation of patients undergoing high risk elective gynaecological surgery

VMMC and Safdarjung Hospital1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2024年8月31日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
120
试验地点
1
主要终点
To assess partial pressure of oxygen in intraoperative arterial blood gas sample as a predictor of successful tracheal extubation in patients undergoing high risk elective gynaecological surgery

研究概览

简要总结

Extubation in high risk surgeries involves many factors including ventilation, oxygenation, hemodynamics, fluid status and blood loss. Extubation carries a risk of reintubation. A comprehensive tool is needed to assess these factors and Arterial Blood Gas i.e ABG is one such tool. Extubation criteria used in OT focusses on subjective measures like head raising, following commands and verbal response which can be unreliable. ABG offers a more objective assessment, potentially improving extubation decisions in high risk surgeries. While ABG analysis is widely used to make extubation decisions in ICU settings, there is limited data on their use in OT settings. Patients planned for high risk elective gynaecological surgery will be recruited in the study according to inclusion and exclusion criteria after taking written informed consent. Patient will be taken to OT, general anaesthesia will be given and airway will be secured by an appropriate size cuffed endotracheal tube and standard anaesthesia protocol will be followed. Intraoperative hemodynamic parameters will be monitored and ABGs will be done as per patient requirement. ABG taken just before extubation will be analysed in the study for parameters like PaO2, PaCO2, pH and Bicarbonate levels. Following fulfillment of standard extubation criteria according to departmental anaesthesia protocol, patient will be extubated and followed up for 24 hours post operatively to look for any reintubation. Those not meeting extubation criteria and sent to ICU will also be observed for 24 hours. ABG values will be compared between patients who are successfully extubated in OT with those reintubated within 24 hours postoperatively.

研究设计

研究类型
Interventional
分配方式
Na
盲法
None

入排标准

年龄范围
18.00 Year(s) 至 80.00 Year(s)(—)
性别
Female

入选标准

  • Female patients aged above 18 years planned for elective gynaecological oncological surgery under general anaesthesia requiring endotracheal intubation.

排除标准

  • 1.Known case of Chronic kidney disease, Chronic obstructive pulmonary disease, Renal tubular acidosis, polytrauma
  • Pregnancy
  • Severe sepsis and septic shock.

结局指标

主要结局

To assess partial pressure of oxygen in intraoperative arterial blood gas sample as a predictor of successful tracheal extubation in patients undergoing high risk elective gynaecological surgery

时间窗: Arterial blood gas sample will be taken 10 minutes before tracheal extubation

次要结局

  • To assess partial pressure of Carbon dioxide, bicarbonate level & pH in intraoperative arterial blood gas sample as a predictor of successful tracheal extubation in patients undergoing high risk elective gynaecological surgery(Arterial blood gas sample will be taken 10 minutes before tracheal extubation)

研究者

发起方
VMMC and Safdarjung Hospital
申办方类型
Government medical college
责任方
Principal Investigator
主要研究者

Dr Shreya Sharma

VMMC and Safdarjung Hospital

研究点 (1)

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