Correlation Between Inflammatory Markers and Complete Blood Film Indices (White Blood Cells and Platelets ) in Severely Malnourished Children
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 主要终点
- correlate between inflammatory markers and cbc indices in severly malnourished children
研究概览
简要总结
The main objectives of this study were to correlate between inflammatory markers and cbc indices in severly malnourished children and to determine whether children with SAM can mount an acute phase reactant response namely CRP and to evaluate the usefulness of quantitative CRP as a predictor of severe infections in children with SAM.
And to correlate between inflammatory markers and CBC indices (mainly white blood cells and platelets in those children .
详细描述
Malnutrition remains one of the most common causes of morbidity and mortality among children throughout the world.
Malnutrition is a pathological state resulting from a relative or absolute deficiency or excess of one or more essential nutrients it may be clinically manifested or detected by biochemical ,anthropometric measurements In 2009, the World Health Organization (WHO) estimated that 20 million children under 5 years suffered from severe acute malnutrition (SAM) worldwide, which is associated to more than half of their deaths each year in developing countries.
Severe acute malnutrition is defined by a very low weight for height ( below -3z scores of the median WHO growth standards ,by visible severe wasting or by presence of nutritional edema It diminishes immune function and prevents the host from mounting an adequate protective response to infectious agents. In turn, infections alter nutrient status and can create a deficiency state. Thus, malnutrition and infection often act synergistically to increase morbidity and mortality, particularly among infants and children The usual signs of infection are absent or nonspecific in children with acute severe malnutrition (SAM), Furthermore, laboratory diagnostic capacity is often limited in regions with the highest burdens of malnutrition.
Malnourished patients maintain the capacity to release inflammatory markers such as CRP & Interleukin-6 which can be considered favorable for combating infections.
Malnourished patients maintain the capacity to release inflammatory markers such as CRP which can be considered favorable for combating infections.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Months 至 5 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All children aged 6 months up to 5 years who were admitted with the diagnosis of SAM .
- •The diagnosis of SAM was made using the recent WHO criteria measuring weight for length/height and mid-upper arm circumference (MUAC) and the presence of bilateral pitting oedema and severe wasting. Two forms of SAM exist in children: nonoedematous malnutrition, also known as marasmus, characterized by severe wasting and currently defined by weight for length/height z score < -3 of the WHO growth standard, or MUAC <11.5 cm; and edematious malnutrition defined by bilateral pitting edema also known as Kwashiorkor.10 The term marasmic kwashiorkor, has been used to describe children with both wasting and edema.
排除标准
- •Children below 6 months or above 5 years
- •Children with mild and moderate malnutrition,
- •Children with malnutrition secondary to serious underlying conditions including
- •Congenital anomalies, inborn errors of metabolism, malignancies, inherited autosomal disorders like cystic fibrosis, chronic diarrhial diseases like coeliac disease,
- •Congenital cardiac diseases, chronic kidney disease were excluded from the study.
结局指标
主要结局
correlate between inflammatory markers and cbc indices in severly malnourished children
时间窗: baseline
to determine whether children with SAM can mount an acute phase reactant response namely CRP and to evaluate the usefulness of quantitative CRP as a predictor of severe infections in children with SAM. And to correlate between inflammatory markers and CBC indices (mainly WBCS and platelets in those children .
次要结局
未报告次要终点
研究者
Meret Michael Fahmy
doctor
Assiut University