Impact of Vaccenic Acid Consumption on the Metabolism of Saturated Fatty Acids: Relationship With Cardiovascular Risk Factors
Not Applicable
Completed
- Conditions
- Cardiovascular Disease
- Registration Number
- NCT00685581
- Brief Summary
The investigators' project has for principal objective to evaluate the impact of three specific ruminant milk fats with a Trans Fatty Acid content ranging from 2.9% to 12.2% obtained by modification of the cow's diet on cardiovascular risk factors in healthy subjects.
- Detailed Description
111 healthy, normolipemic men and women (18y to 50y) have been recruited for a monocentric, randomised, double-blind, controlled 4-week study. All the volunteers consumed 3 experimental products (butter, dessert cream and cakes) made with one of the 3 specific milk fats up to 55 g fat/day.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 107
Inclusion Criteria
- HDL cholesterol, g/L > 0.4
- Triacylglycerol g/L <1.50
- LDL Cholesterol g/L <1.60
- Waist size < 94 cm (men) or 80 cm (women)
- Affiliated to National Health Insurance
- Normal blood pressure (diastolic <90 mm Hg, systolic <140 mm Hg)
- For women: effective contraception
- Subject giving his/her written informed consent
- Subject willing to comply with the study procedures
Exclusion Criteria
- Reported food allergies
- Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study
- Hepatic or renal impairments
- Positive serologies to HIV or HCV,
- Blood donation done less than 2 months before the start of the study
- Chronic pathologies
- Refusal to be registered on the National Volunteers Data file
- Being in exclusion on the National Volunteers Data file
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method HDL-cholesterol
- Secondary Outcome Measures
Name Time Method total cholesterol LDL-cholesterol triglycerides apolipoprotein
Trial Locations
- Locations (1)
Centre de Recherche en Nutrition Humaine (CRNH), UEN, Laboratoire de Nutrition Humaine
🇫🇷Clermont-Ferrand, France
Centre de Recherche en Nutrition Humaine (CRNH), UEN, Laboratoire de Nutrition Humaine🇫🇷Clermont-Ferrand, France