Comparison of three drugs named metronidazole, tinidazole and secnidazole for effectiveness in patients of liver abscess
Phase 3
- Conditions
- Health Condition 1: K750- Abscess of liver
- Registration Number
- CTRI/2022/01/039430
- Lead Sponsor
- Dr BSA Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All consenting patients presenting to surgery opd/emergency in given duration of time with evidence of single liver abscess.
Exclusion Criteria
1.USG evidence of presence of multiple liver abscesses.
2.Clinical signs and symptoms of intraperitoneal rupture of abscess.
3.Very sick patient requiring ICU admission
4.Age <10 years or >60 years
5.Pregnant women
6.Patient with history of malignancy past or present
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the efficacy of Metronidazole vs Tinidazole vs Secnidazole in a triple arm randomised controlled trial study in patients of Amoebic Liver Abscess.The efficacy will be assessed by resolution of symptoms and signs like fever, abdominal pain, right hypochondrium tenderness and leucocytosis.Timepoint: At 1 month and 3 months from date of discharge
- Secondary Outcome Measures
Name Time Method 1.To compare the incidence of complications like intra peritoneal rupture, pleural effusion, atelectasis <br/ ><br>2.To report drug related side effect like nausea, metallic taste, peripheral neuropathy, caecal perforation, colitis <br/ ><br>3.Patient Satisfaction Score <br/ ><br>Timepoint: At 1 month and 3 months from date of discharge