Double Filtration Plasmapheresis (DFPP) and Lipid Metabolism

Not Applicable

• Conditions: DFPP and Platelet Function
• Interventions: Device: DFPP

• Registration Number: NCT03491956
• Lead Sponsor: Shanghai Pudong Hospital

Brief Summary

Little clinic trials showed that Double Filtration Plasmapheresis (DFPP) could improve lipid metabolism, however, whether DFPP can improve platelet function and recover Endothelial function is unknown. In this study, we try to confirm the hypothesis that DFPP can improve endothelial function in hyperlipidemia patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-02-01
• Study First Submitted: 2018-04-02
• Study First Submitted QC: 2018-04-02
• Study First Posted: 2018-04-09
• Status Verified: 2021-03
• Last Update Submitted: 2021-03-16
• Last Update Posted: 2021-03-17
• Primary Completion: 2021-04-01
• Study Completion: 2021-04-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. hyperlipidemia

Exclusion Criteria

1. Severe liver and kidney dysfunction
2. Severe cardiopulmonary insufficiency
3. tumor
4. pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
DFPP group	DFPP	self contrast (before and after DFPP)

Primary Outcome Measures

Name	Time	Method
lipid levels	1 year	reduce in lipid levels

Secondary Outcome Measures

Name	Time	Method
Platelet RNA sequencing	1 year	whether the RNA sequencing of platelet changed ?

Trial Locations

Locations (1)

Shanghai Pudong Hospital; 🇨🇳 Shanghai, Shanghai, China