Effects of zinc and vitamin D separately and in combination on mood in overweight and obese subjects
Phase 3
- Conditions
- obesity.Simple obesity NOS
- Registration Number
- IRCT201601252394N31
- Lead Sponsor
- Vice Chancellor for Research, Iran University of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 140
Inclusion Criteria
age between 20 to 60 years old; BMI > 27; willing to participate; weight stable in 3 last months. Exclusion criteria: Having a history of coronary artery disease; acute or chronic renal failure; acute or chronic hepatic failure; presence of any chronic inflammatory and autoimmune disease; and any known malignancy; hormone therapy; Other non-pathological exclusion criteria included pregnancy; breast feeding; post-menopause; smoking, professional athlete; uncontrolled thyroid disorder; use of medications for dyslipidemia or hypertension; having a special diet for any reason prescribed by the clinic dietitian; consumption of nutritional supplements within the past 8 weeks.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mood. Timepoint: At baseline and after weeks 12. Method of measurement: Beck Depression Inventory.;Serum cortisol. Timepoint: At baseline and after weeks 12. Method of measurement: ELISA.;Serum tryptophan. Timepoint: At baseline and after weeks 12. Method of measurement: ELISA.;Serum kynurenine. Timepoint: At baseline and after weeks 12. Method of measurement: ELISA.;Serum BDNF. Timepoint: At baseline and after weeks 12. Method of measurement: ELISA.
- Secondary Outcome Measures
Name Time Method Serum hs-CRP. Timepoint: At baseline and after weeks 12. Method of measurement: ELISA.