Vitamin D Levels and Postoperative Hypocalcemia After Total Thyroidectomy

• Conditions: Vitamin D Deficiency; Hypocalcemia; Hypoparathyroidism; Thyroidectomy

• Registration Number: NCT01039714
• Lead Sponsor: Aristotle University Of Thessaloniki

Brief Summary

Hypocalcemia is one of the most frequent complications of total thyroidectomy, a procedure used for benign as well as malignant conditions of the thyroid gland. Postoperative hypocalcemia is usually caused by hypoparathyroidism. Vitamin D is implicated in calcium metabolism as it increases intestinal calcium transport and regulates parathormone production. Aim of the present study is to evaluate preoperative vitamin D levels as a prognostic factor for postoperative hypocalcemia and hypoparathyroidism.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2009-09-29
• Status Verified: 2009-12
• Study Start: 2009-12
• Study First Submitted QC: 2009-12-24
• Last Update Submitted: 2009-12-24
• Study First Posted: 2009-12-25
• Last Update Posted: 2009-12-25
• Primary Completion: 2010-04
• Study Completion: 2010-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Patient is over 18 years old
2. Patient scheduled for total thyroidectomy
3. Patient signs and dates a written informed consent form (ICF) and indicates an understanding of the study procedures

Exclusion Criteria

1. Primary hyperparathyroidism
2. Primary hypoparathyroidism
3. Chronic Renal Failure
4. Hypoalbuminemia
5. Neck irradiation
6. Systematic Diseases (e.g., infections)
7. Thyroid or parathyroid cancer
8. Osteoporosis
9. Drugs that influence calcium metabolism (vitamin D analogues, oral calcium supplements, biphosphonates, teriparatide, thiazide diuretics)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Impact of preoperative vitamin D levels on postoperative hypocalcemia after total thyroidectomy.	24 hours postoperatively

Secondary Outcome Measures

Name	Time	Method
Impact of preoperative vitamin D levels on parathyroid function after total thyroidectomy.	24 hours postoperatively

Trial Locations

Locations (1)

AHEPA University Hospital Thessaloniki, Greece; 🇬🇷 Thessaloniki, Makedonia, Greece