Effects of Stevia on Satiety and Eating Attitudes in Healthy, Overweight and Obese Adults: A Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels.
研究概览
简要总结
The purpose of this study is to test the effects that three different types of sweeteners have on food intake, hunger and satiety levels, as well as insulin and glucose measures. The study of whether food or beverages containing Stevia influence food intake to a greater extent than food or beverages sweetened with Aspartame or Sucrose. Also, examining whether taste preference and taste sensitivity influence food intake.
详细描述
Expected time in this study will be approximately 24 hours spread over the course of one initial screening visit and three test days during which you complete food tests at the Pennington Center.
Screening visit (Duration is 3 hours)
- You will initially be asked to fill out psychological questionnaires to assess your eating habits, food cravings, and preference for foods (i.e., tea and crackers with cream cheese) that will be provided to you in this study.
- You will also be asked to complete two taste tests during this visit. The first taste test will be sodium chloride (table salt) followed by PROP (an extremely low dose of hyperthyroid medication) sodium chloride (table salt).
- You will be required to provide a blood sample (19 mL or 1.3 tablespoons) to check glucose and insulin levels.
- If you are selected to be a participant for this study, you will receive a brief medical evaluation during which you will be weighed, your height will be measured, and your pulse and blood pressure will be taken. You will be interviewed about your medical history and potential obstacles for completing the study. If you are female, a brief interview will be conducted to determine your menstrual cycle phase. Total length of time will be approximately three hours for the screening visit.
First Food Test Day (Duration is 7- 9 hours. You'll arrive after having fasted for 12 hrs.) For females, all test meal days will be scheduled during their luteal phase. • Breakfast: During your first food test day, you will be asked to come to the Pennington Center at any time between the hours of 7:00 A.M. - 8:30 A.M. and consume a standard breakfast of Cheerios, milk, orange juice, toast, butter, and jelly. You will then be free to leave but will be asked to return 3.5 hours later. When your return, you will be sent to our inpatient unit for a blood draw, which will test your level of insulin and glucose (total of 25 mL or 1.67 tablespoons). You will then be asked to rate your appetite on a computer using a visual analog scale (VAS). After completing these VAS ratings, you will be provided with an appetizer of 5 ounces of cold tea and 6 crackers with cream cheese. Both the tea and the cream cheese will be sweetened with one of the following sweeteners: Aspartame, Sucrose, or Stevia. After consuming this appetizer, you will be asked to complete another set of VAS ratings, which again ask you about your appetite, as well as the sweetness of the appetizer. Test times will be constant for all visits. Approximately twenty minutes after consuming this appetizer, your insulin and glucose levels will again be tested and you will complete another set of VAS ratings before your lunch meal. You will be required to consume breakfast at the same time for all three visits. For example, if you come at 7:00 A.M. on your first test day, you will be required to come in at 7:00 A.M. on your next two test days.
• Lunch: After completing VAS ratings before lunch, you will be provided with a lunch consisting of sandwiches, chips, and cookies. Your lunch meal will be served approximately 4 hours after your breakfast meal. Your eating behavior may be monitored by weight of the food consumed and/or by video camera/tape. You may eat as much or as little of the lunch as you wish.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy and have a body mass index > 30 kg/m2 and < 39.9 kg/m2, or have a body mass index > 20 kg/m2 and < 24.9 kg/m2
- •If BMI is between 30 and 39.9, waist circumference must be > 36 for women and > 40 for men.
- •Age 18 to 45 years
- •Nonsmokers
- •Willing to consume meat products
- •Women on monophasic oral contraceptives or who have physiologically controlled cycles
排除标准
- •A history of diabetes, cardiovascular disease, or other chronic illnesses
- •Presence of an eating disorder including Anorexia and/or Bulimia Nervosa
- •Other health problems that might interfere with your ability to participate in the study
- •Taking medications, other than monophasic birth control or monophasic (same dose every day) hormone replacement therapy and allergy medication
- •Taking allergy medication for a period of time less than 6 months
- •Dislike of or allergy to foods/sweeteners (Sucrose, Stevia, or Aspartame) used in test meals
- •High scores on the Dietary Restraint, Disinhibition, and Perceived Hunger scales of the Three Factor Eating Questionnaire
- •Use of oral contraceptives other than monophasic (same dose every day) contraceptives
结局指标
主要结局
Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels.
时间窗: 24 hours
Test whether preloads of tea and crackers with cream cheese sweetened with Stevia lover postprandial insulin levels compared to preloads of tea and crackers with cream cheese sweetened with Sucrose or Aspartame by measuring blood insulin and glucose levels immediately prior to the lunch preload,immediately before lunch test meal, and at thirty minutes, one hour, and two hours after the lunch test meal.
次要结局
- Hedonic ratings (appearance, aroma, flavor, texture and palatability)with Stevia sweetener compared to Sucrose or Aspartame(24 hours)
- Satiating effects by examining food consumption(24 Hours)
研究者
William Cefalu, MD
Executive Director
Pennington Biomedical Research Center