Effects of Different Types of Exercise Interventions in Patients With Type 2 Diabetes
- Conditions
- Type 2 Diabetes
- Interventions
- Other: Aerobic endurance training interventionOther: Strength endurance training interventionOther: Combined aerobic endurance and strength endurance training
- Registration Number
- NCT01377558
- Lead Sponsor
- University of Giessen
- Brief Summary
The purposes of the study are
* to determine which kind of supervised exercise intervention (aerobic endurance training versus strength endurance training versus combined aerobic endurance and strength endurance training) is more effective in improving the metabolic parameters in typ 2 diabetes patients
* to investigate what kind of intervention is more successful in reduction of concomitant diseases and improving quality of life
* to assess what kind of intervention induces highest effects in long term persistence of these positive changes
- Detailed Description
Meta-analyses which evaluated the effects of structured exercise programs in patients with type 2 diabetes demonstrate that regular physical activity improves glycosylated haemoglobin (König et al.: Resistance Exercise and Type 2 Diabetes Mellitus, Deutsche Zeitschrift für Sportmedizin Jahrgang 62, Nr. 1 (2011): 5-9). Sigal et al. proved that either aerobic or resistance training alone improved glycemic control in type 2 diabetes, but the improvements are greatest with combined aerobic and resistance training (Sigal, RJ, et al.: Effects of Aerobic Training, Resistance Training, or Both on Glycemic Control in Type 2 Diabetes, Ann Intern Med. 2007 Sep 18;147(6):357-69).
Therefore, aim of the current study is to compare the effects of aerobic endurance training or resistance endurance training or the combination of aerobic endurance training and resistance endurance training in diabetes type 2 patients without any other lifestyle or dietary interventions.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- diagnoses of type 2 diabetes (ADA criteria)
- admitted diabetes treatments will be diet and oral hypoglycemic agents
- sports intervention >60 minutes per week
- medical conditions
- preproliferative or proliferative retinopathy
- instable coronary heart disease
- inability to perform the scheduled physical activity programs
- acute clinically significant intercurrent diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Aerobic endurance training intervention Aerobic endurance training intervention Aerobic endurance training Strength endurance training intervention Strength endurance training intervention Strength endurance training Combined training intervention Combined aerobic endurance and strength endurance training Combined aerobic endurance training and strength endurance training intervention
- Primary Outcome Measures
Name Time Method Change in HbA1c-level (haemoglobin A1c) 6 months
- Secondary Outcome Measures
Name Time Method Change in HOMA-Index 3 and 6 months Change in beta-cell-function 3 and 6 months Measured by OGTT (Oral Glucose Tolerance Test)
Change in fasting plasma glucose levels 3 and 6 months Change in total cholesterol levels 3 and 6 months Change in HDL-cholesterol levels 3 and 6 months Change in LDL-cholesterol levels 3 and 6 months Change in triglyceride levels 3 and 6 months Change in antidiabetic medications 3 and 6 months Class and dosage of blood-glucose lowering drugs are recorded before, after 3 and 6 months
Change in inflammation markers 3 and 6 months CrP, blood count, interleukinstatus, cytokinstatus
Change in body weight 3 and 6 months Change in body composition 3 and 6 months by Bio-impedance analysis, waist to hip ratio, range of thigh
Change in strength 3 and 6 months by Dr. Wolff Back Check
Change of maximum heart rate 3 and 6 months Measured by an incremental exercise test
Change of peak oxygen uptake 3 and 6 months Measured by an incremental exercise test
Change of vAT (ventilatory anaerobic threshold) 3 and 6 months Measured by an incremental exercise test
Change in blood pressure 3 and 6 months Change in renal function 3 and 6 months Creatininlevel, Albuminlevel (urine), Telomere length
Change in concentration 3 and 6 months by d2-test
Change in quality of life 3 and 6 months by questionnaire: SF-12, EQ5
Change of nutrition 3 and 6 months by questionnaire: FEV, FFQ
Change in voluntary physical activity 3 and 6 months meassured by pedometer (one week)
Change of cardiac output by Impedance cardiography 3 and 6 months by Task Force Monitor
Change of barorezeptorsensitivity 3 and 6 months by Task Force Monitor
Change in carotid-Intima-Media-Thickness 3 and 6 months Change in aortic pulse-wave velocity 3 and 6 months Change in central aortic pressure 3 and 6 month Change in endothelial dysfunction 3 and 6 months Change of parodontitis 3 and 6 months Follow up of all parameters mentioned above after 12 months Follow up after 12 months (6 months after completing the exercise intervention) without any supervised intervention
Trial Locations
- Locations (2)
Sportpark Zwickau, Glauchau, Meerane
🇩🇪Zwickau, Sachsen, Germany
University of Giessen
🇩🇪Giessen, Hessen, Germany