Cogmed Training Effect in Hypertensive Patients With Cognitive Impairment: a Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Working memory score
研究概览
简要总结
Systemic arterial hypertension is a disease with high prevalence in several countries, including Brazil. Many studies have correlated hypertension with accelerated loss of cognitive function, especially executive functions. There is some evidence that working memory (WM) is compromised in these populations. However, some computerized training has been developed to rehabilitate the WM, and among them the investigators highlight the Cogmed. Thus, the aim of this study is to evaluate the effects of Cogmed training in the performance of WM and attention of hypertensive patients, as well as the impact of training in the structure and brain function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals of both genders, of any ethnicity
- •Signing the consent form
- •Access to computer with internet at home
- •Inexperienced to computerized cognitive training
- •Hypertensive pre-diagnosed
- •Basic schooling of four years
- •Cognitive impairment
排除标准
- •Marked functional limitation
- •Cognitive limitation or serious communication
- •Severe neurological and psychiatric diseases
- •Stroke history, head trauma or substance abuse
研究组 & 干预措施
Adaptive training group
The intervention group will be composed of hypertensive participants with cognitive decline that will be submitted to the training program (Cogmed) for approximately 10 weeks. Across training, task difficulty was adjusted as a function of individual performance.
干预措施: Cogmed (Other)
Active control Group
In the control group, hypertensive patient will be submitted to a set of online games available on the internet and previously determined. In this way, the control group will receive the same motivation, as well as will be engaged in computerized activities, in the same way as the experimental group. The difference is that these varied games do not provide any type of intense and adaptive training, at the same time as they do not stimulate any specific cognitive function.
干预措施: Cogmed (Other)
结局指标
主要结局
Working memory score
时间窗: 10 weeks
Backward Digits Test / Letter-Number Sequencing (WAIS-III): total score (sum of right answers)
次要结局
- Brain function(10 weeks)
- Verbal memory score(10 weeks)
- Visual memory score(10 weeks)
- Executive functions score(10 weeks)
研究者
Regina Silva Paradela
PhD student
University of Sao Paulo General Hospital