Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis
试验速览
- 阶段
- 2 期
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- The detection of sarcoidotic lesion with C11-methionine or 68Ga-DOTANOC.
研究概览
简要总结
The goal of the current study is to evaluate the potential of the selected PET tracers to detect sarcoidotic lesions in lungs. The tracers are already in clinical use for the detection of certain inflammatory processes or malignant tumors, and their targets present similarities with molecular mechanisms of sarcoidosis.
详细描述
The diagnosis of sarcoidosis is difficult since there is no specific noninvasive method available to diagnose sarcoidosis. FDG-PET imaging is in use, however, FDG is not a specific tracer for sarcoidosis and other inflammatory diseases may interfere with the imaging findings. The aim of the current protocol is to evaluate the potential of other inflammatory PET-tracers in the detection of sarcoidotic lesions.
The patients with active sarcoidotic lesions in lungs will be recruited. First, the patient undergoes PET-FDG scan and then the patient undergoes the PET scan either with C11-methionine or 68Ga-DOTANOC. The results with the latter tracers will be compared to the imaging results with FDG.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with sarcoidosis
排除标准
- •any malignant disease
- •any significant other inflammatory or infectious disease affecting lungs
- •pregnancy
研究组 & 干预措施
C11-methionine
To compare FDG and C11-methionine in the detection of sarcoidotic lesions.
干预措施: Methionine (Drug)
68Ga-Dotanoc
To compare FDG and 68Ga-DOTANOC in the detection of sarcoidotic lesions.
干预措施: DOTANOC (Drug)
结局指标
主要结局
The detection of sarcoidotic lesion with C11-methionine or 68Ga-DOTANOC.
时间窗: baseline
Qualitative assessment of tracer uptake in sarcoidotic lesions.
次要结局
未报告次要终点