Observational Cohort Study to Evaluate Immunogenicity, Protection, and Persistence of Antibody to Mumps in 3-7 Years' Children Received One-dose Mumps-containing Vaccine
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7,901
- 试验地点
- 6
- 主要终点
- to describe the sero-prevalence in specific age groups following an active surveillance of vaccinated subjects in each year
研究概览
简要总结
This study was aimed to conduct a 3-year perspective study to observe the immunological effect of one-dose mumps-containing vaccine, monitor the incidence of mumps in vaccinated population aged 3-7 years，and provide basis for adjusting MMR immunization strategy in Jiangsu province, China.
详细描述
in 3-7 years old children with high risk of mumps, epidemiological investigation of the serum IgG antibody level were conducted, and then a prospective observational cohort was established in the population with a history of mumps vaccination, and the incidence of mumps in each antibody level group will be observed, the relationship between different antibody levels and the incidence after mumps vaccinated were analyzed, to explore attenuation of mumps IgG antibody levels in the body,S79 vaccine strain against F genotype mumps' antigenic cross-reactivity and the protective effect of antibodies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Years 至 7 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children aged 3-7 years old;
- •local resident children living at least 3 months;
- •physical health, has been vaccinated at least once a dose of MuV
排除标准
- •did not administer MuV;
- •refused to collect venous blood;
- •have been infected with mumps;
- •have serious illness or other reasons should not participate in the study after clinical evaluation
结局指标
主要结局
to describe the sero-prevalence in specific age groups following an active surveillance of vaccinated subjects in each year
时间窗: 3 years
次要结局
- to describe wane immunity of IgG antibody to mumps virus in specific age groups following an active surveillance of vaccinated subjects in each year(3 years)
- To characterize the incidence of mumps in specific age groups following an active surveillance of vaccinated subjects in each year(3 years)