NCT05458843已完成不适用
Renal Considerations in the Heat Stress and Hydration Recommendations (Aim 2)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Peak urinary thioredoxin
研究概览
简要总结
An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is largely unknown, but may be related to kidney dysfunction caused by increases in body temperature and dehydration that elicit oxidative stress and inflammation in the renal tubules. The purpose of this study is to determine whether hydration status modifies the development of renal oxidative stress and inflammation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 44 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women
- •18-44 y old
- •Body mass index ≤35.0 kg/m2
- •Self-reported to be healthy
排除标准
- •Not within defined age range
- •Estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2
- •Body mass index >35.0 kg/m2
- •Current or history of any renal disease, heart disease, stroke, immune or autoimmune disease, and/or gastrointestinal disease/surgery
- •Hypertension during screening (systolic blood pressure >139 or diastolic blood pressure >89)
- •Using medications that blunt the physiological response to exercise (e.g., beta blockers)
- •Prescription medication with a known side effect of impaired temperature regulation or fluid balance (e.g., diuretics)
- •Positive pregnancy test at any time during the study or breast feeding
- •Current tobacco or electronic cigarette use or consistent use within the last 2 years
- •Answered "Yes" to any question on Page 1 of the PAR-Q+.
结局指标
主要结局
Peak urinary thioredoxin
时间窗: Through study completion, up to twelve weeks
Marker of renal oxidative stress
Peak urinary MCP-1
时间窗: Through study completion, up to twelve weeks
Marker of renal inflammation
次要结局
- Peak urinary [IGFBP7 x TIMP-2](Through study completion, up to twelve weeks)
- Segmental artery blood velocity(Through study completion, up to twelve weeks)
- Renal artery blood velocity(Through study completion, up to twelve weeks)
研究者
Zachary J. Schlader
Associate Professor Kinesiology
Indiana University
研究点 (2)
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