Predictors of Acute and Persistent Postoperative Pain in Lung Cancer Surgery
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Lung Cancer
- Sponsor
- Jannie Bisgaard Stæhr
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Numerical Rating Scale
- Status
- Active, Not Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The aim of this observational study is to investigate if preoperative quantitative sensory testing, anxiety and depression symptoms, and biological markers are associated with the risk of developing acute and chronic postoperative pain after video-assisted Thoracoscopic surgery (VATS).
Detailed Description
This observational study examine acute and chronic postoperative pain in patients undergoing VATS. In the study preoperative biomarkers, quantitative sensory testing and questionnaires are used to create prediction models for acute and chronic postoperative pain. The study will serve as background information on the risk factors and predictive factors as well as an exploration of the impact of surgical stress from VATS on circulation microRNA and inflammatory mediators.
Investigators
Jannie Bisgaard Stæhr
Chief Physician
Aalborg University Hospital
Eligibility Criteria
Inclusion Criteria
- •Adults independent of sex with an age of ≥ 18 years
- •Patients scheduled for VATS as a part of either examination or radical treatment of lung cancer
Exclusion Criteria
- •Patients who are unable to understand oral and written information.
- •Patients with known chronic pain in the thorax which have been persisting for at least six months before the day of surgery.
- •Pregnant and nursing women.
- •Patients receiving a planned preoperative epidural blockade during their stay.
- •Patients converted to open surgery.
Outcomes
Primary Outcomes
Numerical Rating Scale
Time Frame: 365 days postoperative
Pain intensity on a Numerical Rating Scale ranging from 0 indicating no pain to 10 indicating worst pain imaginable at follow up. Collected using the Brief Pain Index
Secondary Outcomes
- Total equipotent opioid dose(Total equipotent opioid dose in milligrams during the first 48 hours after surgery.)
- Time to first administration of opioid(Time in hours to first postoperative administration of Pro Re Nata (PRN) opioids)
- Mobilisation(48 hours postoperative)
- Patient-reported satisfaction of postoperative pain management assessed by self-made questionnaire in Danish(Measured twice. Once 48 hours after surgery or at non fixed time(on average 4 days and a maximum of 3 months) as well as at 365 days)