Predictors of Acute and Persistent Postoperative Pain in Lung Cancer Surgery
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Numerical Rating Scale
研究概览
简要总结
The aim of this observational study is to investigate if preoperative quantitative sensory testing, anxiety and depression symptoms, and biological markers are associated with the risk of developing acute and chronic postoperative pain after video-assisted Thoracoscopic surgery (VATS).
详细描述
This observational study examine acute and chronic postoperative pain in patients undergoing VATS. In the study preoperative biomarkers, quantitative sensory testing and questionnaires are used to create prediction models for acute and chronic postoperative pain. The study will serve as background information on the risk factors and predictive factors as well as an exploration of the impact of surgical stress from VATS on circulation microRNA and inflammatory mediators.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults independent of sex with an age of ≥ 18 years
- •Patients scheduled for VATS as a part of either examination or radical treatment of lung cancer
排除标准
- •Patients who are unable to understand oral and written information.
- •Patients with known chronic pain in the thorax which have been persisting for at least six months before the day of surgery.
- •Pregnant and nursing women.
- •Patients receiving a planned preoperative epidural blockade during their stay.
- •Patients converted to open surgery.
结局指标
主要结局
Numerical Rating Scale
时间窗: 365 days postoperative
Pain intensity on a Numerical Rating Scale ranging from 0 indicating no pain to 10 indicating worst pain imaginable at follow up. Collected using the Brief Pain Index
次要结局
- Total equipotent opioid dose(Total equipotent opioid dose in milligrams during the first 48 hours after surgery.)
- Time to first administration of opioid(Time in hours to first postoperative administration of Pro Re Nata (PRN) opioids)
- Mobilisation(48 hours postoperative)
- Patient-reported satisfaction of postoperative pain management assessed by self-made questionnaire in Danish(Measured twice. Once 48 hours after surgery or at non fixed time(on average 4 days and a maximum of 3 months) as well as at 365 days)
研究者
Jannie Bisgaard Stæhr
Chief Physician
Aalborg University Hospital