Validity of the Electronic Self-Administered Gerocognitive Examination (eSAGE)

Completed

Conditions: Mild Cognitive Impairment
Dementia

Interventions: Behavioral: eSAGE testing
Behavioral: neuropsychological testing

Registration Number: NCT02544074

Lead Sponsor: Ohio State University

Brief Summary: The Self-Administered Gerocognitive Examination (SAGE) is a valid and reliable cognitive assessment tool used to identify both Mild Cognitive Impairment (MCI) and early dementia. SAGE's self-administered feature, pen and paper format, and four equivalent interchangeable forms allows it to be given in almost any setting, does not require any staff time to administer and makes it practical to rapidly screen large numbers of individuals in the community or in their home.This trial is being conducted to study the validity of SAGE in a digital format (eSAGE) for cognitive screening.

The investigators will analyze the data to learn the correlations between eSAGE and gold standard neuropsychological testing designed to differentiate normal cognition from MCI and early dementia. The investigators will also find out whether the paper (SAGE) and electronic (eSAGE) versions of SAGE could be used interchangeably or not.

Addendum:

The eSAGE was previously validated in an earlier stage of this trial. It was initially designed for tablet use and the exact same test has recently been formatted for smartphone use.

This addendum is being conducted to study the validity of the smartphone eSAGE compared to the tablet eSAGE for cognitive screening.

Detailed Description: Participants will be recruited based on their eSAGE scores and evaluated with neuropsychological testing and medical history to determine their status as normal, mild cognitive impairment, or dementia.

The investigators will analyze the data to learn the correlations between eSAGE and gold standard neuropsychological testing designed to differentiate normal cognition from MCI and early dementia. The investigators will also find out whether the paper (SAGE) and electronic (eSAGE) versions of SAGE could be used interchangeably or not.

Addendum:

Subjects will be scheduled for a one time visit where they will be administered both the tablet eSAGE and the smartphone eSAGE. eSAGE tablet scores will be compared to eSAGE smartphone scores to determine if the two formats are equivalent to each other.

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 69

Inclusion Criteria

Adults over 49 years old of either gender
Vision and hearing sufficient for compliance with tests

Exclusion Criteria

Diagnosis by a physician of moderate or severe dementia
Intellectual disability

Study & Design

Study Type: OBSERVATIONAL

Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Smartphone eSAGE score of 13	eSAGE testing	Participants who score a 13 on the smartphone eSAGE. Interventions include neuropsychological testing.
eSAGE score of 2	neuropsychological testing	Participants who score a 2 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 11	neuropsychological testing	Participants who score an 11 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 14	neuropsychological testing	Participants who score a 14 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 22	neuropsychological testing	Participants who score a 22 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 6	neuropsychological testing	Participants who score a 6 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 3	neuropsychological testing	Participants who score a 3 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 10	neuropsychological testing	Participants who score a 10 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 13	neuropsychological testing	Participants who score a 13 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 15	neuropsychological testing	Participants who score a 15 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 18	neuropsychological testing	Participants who score a 18 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 4	neuropsychological testing	Participants who score a 4 on the eSAGE. Interventions include neuropsychological testing.
Smartphone eSAGE score of 21	eSAGE testing	Participants who score a 21 on the smartphone eSAGE. Interventions include neuropsychological testing.
eSAGE score of 19	neuropsychological testing	Participants who score a 19 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 8	neuropsychological testing	Participants who score an 8 on the eSAGE. Interventions include neuropsychological testing.
Smartphone eSAGE score of 17	eSAGE testing	Participants who score a 17 on the smartphone eSAGE. Interventions include neuropsychological testing.
eSAGE score of 9	neuropsychological testing	Participants who score a 9 on the eSAGE. Interventions include neuropsychological testing.
Smartphone eSAGE score of 15	eSAGE testing	Participants who score a 15 on the smartphone eSAGE. Interventions include neuropsychological testing.
Smartphone eSAGE score of 19	eSAGE testing	Participants who score a 19 on the smartphone eSAGE. Interventions include neuropsychological testing.
eSAGE score of 12	neuropsychological testing	Participants who score a 12 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 16	neuropsychological testing	Participants who score a 16 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 17	neuropsychological testing	Participants who score a 17 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 20	neuropsychological testing	Participants who score a 20 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 21	neuropsychological testing	Participants who score a 21 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 7	neuropsychological testing	Participants who score a 7 on the eSAGE. Interventions include neuropsychological testing.
eSAGE score of 5	neuropsychological testing	Participants who score a 5 on the eSAGE. Interventions include neuropsychological testing.
Smartphone eSAGE score of 14	eSAGE testing	Participants who score a 14 on the smartphone eSAGE. Interventions include neuropsychological testing.
Smartphone eSAGE score of 16	eSAGE testing	Participants who score a 16 on the smartphone eSAGE. Interventions include neuropsychological testing.
Smartphone eSAGE score of 18	eSAGE testing	Participants who score a 18 on the smartphone eSAGE. Interventions include neuropsychological testing.
Smartphone eSAGE score of 20	eSAGE testing	Participants who score a 20 on the smartphone eSAGE. Interventions include neuropsychological testing.
Smartphone eSAGE score of 22	eSAGE testing	Participants who score a 22 on the smartphone eSAGE. Interventions include neuropsychological testing.

Primary Outcome Measures

Name	Time	Method
eSAGE Score Compared to the Sum of the Neuropsychological Measures.	3 Hours	Analysis will consist of comparing the subject's scores on the SAGE in digital format to their neuropsychological test scores. This will be a composite score of the neuropsychological testing scores. The neuropsychological measures include: * Boston Naming Test * Wisconsin Card Sort Task (WCST) * Hopkins Verbal Learning Test (HVLT) * FAS verbal fluency task * Wechsler Adult Intelligence Scale III (WAIS III) Letter-number and block design subtests Associations will be investigated using Spearman correlations.

Secondary Outcome Measures

Name	Time	Method
eSAGE Score Compared to the Wechsler Adult Intelligence Scale III (WAIS III) Letter-number Score	3 hours	The investigators will compare the eSAGE scores to the WAIS III Letter-number scores. The WAIS III Letter-number test asks subjects to recall a series of numbers in increasing order and letters in alphabetical order. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Montreal Cognitive Assessment (MoCA) Score	3 hours	The investigators will compare the eSAGE scores with the Montreal Cognitive Assessment (MoCA) scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Mini-Mental State Examination (MMSE) Score	3 hours	The investigators will compare the eSAGE scores with the Mini-Mental State Examination (MMSE) scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Hopkins Verbal Learning Test (HVLT) Score	3 hours	The investigators will compare the eSAGE scores to the Hopkins Verbal Learning Test (HVLT) total learning scores. Associations will be investigated using Spearman correlations. The investigators will also compare the eSAGE scores to the Hopkins Verbal Learning Test (HVLT) delayed recall scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Paper SAGE Score	3 hours	The investigators will compare the subject's scores on the SAGE in digital format to their paper SAGE scores to determine if these two formats are equivalent to each other. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Wisconsin Card Sort Task (WCST) Score	3 hours	The investigators will compare the eSAGE scores to the Wisconsin Card Sort Task (WCST) perseverative errors scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compare to the FAS Verbal Fluency Task Score	3 hours	The investigators will compare the eSAGE scores to the FAS Verbal Fluency Task scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Boston Naming Test Score	3 hours	The investigators will compare the eSAGE scores to the Boston Naming Test score. The Boston Naming Test consists of 60 pictures of nouns that subjects must try to name. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Wechsler Adult Intelligence Scale III (WAIS III) Block Design Score	3 hours	The investigators will compare the eSAGE scores to the WAIS III Block Design scores. The WAIS III Block Design requires the replication of red and white designs using three-dimensional colored blocks. Associations will be investigated using Spearman correlations.