Blood Cell RNA-Based Cancer Detection

Recruiting

• Conditions: Cancer; Neoplasms
• Interventions: Diagnostic Test: Blood test

• Registration Number: NCT05839834
• Lead Sponsor: Wuhan Union Hospital, China

Brief Summary

Early diagnosis of cancer may provide patients with more treatment options and hopefully prolong survival. The purpose of this multi-center study is to collect peripheral blood from newly diagnosed cancer patients and healthy donors to establish a blood cell RNA-based model for the differentiation of cancer patients and healthy donors. The area under the receiver operating characteristic (AUROC), sensitivity and specificity of the test in the early detection of multiple cancers will be measured.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-08
• Study First Submitted: 2022-07-12
• Study First Submitted QC: 2023-04-20
• Study First Posted: 2023-05-03
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-22
• Last Update Posted: 2024-07-24
• Primary Completion: 2024-11-01
• Study Completion: 2024-12-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cancer	Blood test	Patients with new diagnosis of cancers
Non-cancer	Blood test	Healthy participants

Primary Outcome Measures

Name	Time	Method
Accuracy of TOO prediction	1 year	Accuracy of the tissue of origin (TOO) prediction of a blood cell RNA-based cancer detection test
Sensitivity and specificity of cancer detection	1 year	Sensitivity and specificity of the early detection of 30 types of cancers of a blood cell RNA-based cancer detection test

Trial Locations

Locations (1)

Zheng Wang; 🇨🇳 Wuhan, Hubei, China