Pressure Controlled Ventilation Versus Volume Controlled Ventilation in Upper Abdominal Surgery

Not Applicable

Completed

• Conditions: Ventilator Lung
• Interventions: Other: Starting with pressure controlled ventilation and changing the ventilation mode every 20 minutes; Other: Starting with volume controlled ventilation and changing the ventilation mode every 20 minutes

• Registration Number: NCT05690867
• Lead Sponsor: Istanbul University

Brief Summary

Comparison of mechanical powers produced at volume controlled and pressure controlled mechanical ventilation

Detailed Description

The mechanical power created by mechanical ventilation, as a new concept, can enable to evaluate the effect of different components in the lung.Our aim in this study is to calculate mechanical power in different ventilation modes ( pressure controlled and volume controlled ventilation) and to compare them. To calculate the mechanical powers we will use Van der Meijden's mechanical power formula for pressure controlled ventilation and for volume controlled ventilation we will use Gattinoni's mechanical power formula. In the literature we haven't seen any publication comparing the mechanical power of two commonly used ventilation modes (volume controlled and pressure controlled ventilation)

Study Timeline

• Study Start: 2022-09-05
• Study First Submitted: 2022-10-18
• Primary Completion: 2022-11-05
• Study Completion: 2022-12-05
• Status Verified: 2023-01
• Study First Submitted QC: 2023-01-18
• Last Update Submitted: 2023-01-18
• Study First Posted: 2023-01-19
• Last Update Posted: 2023-01-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• ASA1-2 , >18 years old patients having upper abdominal surgery

Exclusion Criteria

• chronic obstructive lung disease, interstitial lung disease
• chronic renal failure
• Child-Pugh > 6 liver disease
• Patients who don't give consent
• NYHA > 2 heart failure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Group 2	Starting with pressure controlled ventilation and changing the ventilation mode every 20 minutes	group 2 starts with pressure controlled ventilation
Group 1	Starting with volume controlled ventilation and changing the ventilation mode every 20 minutes	group 1 starts with volume controlled ventilation

Primary Outcome Measures

Name	Time	Method
calculation of mechanical power changes in two different ventilation modes	change from at the beginning of surgery till the end of surgery	mechanical power will be calculated using the Van der Meijden's formula for pressure support ventilation and Gattinoni's formula for volume controlled ventilation and two mechanical powers will be compared

Secondary Outcome Measures

Name	Time	Method
hospitalisation time	up to 20 days	up to 20 days
postoperative pulmonary complications	post-operative 7 days	postoperative pulmonary complication including pneumonia, acute lung injury, respiratory failure requiring reintubation

Trial Locations

Locations (1)

Istanbul University, Department of Anesthesiology; 🇹🇷 Istanbul, Turkey