Intelligence Changes Following Minor Surgery

Withdrawn

• Conditions: Hypospadia; Phimosis; Inguinal Hernia

• Registration Number: NCT01483313
• Lead Sponsor: RenJi Hospital

Brief Summary

Animal studies showed that many general anesthetics might result in neuron apoptosis and neurocognitive impairment in the developing brain. However results from human studies are conflicted. In present study, the investigators examined the association between early exposure to anesthesia and surgery for minor surgery and intelligence changes in adolescence using the Wechsler Intelligence Scale for Children.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-10-13
• Study Start: 2011-11
• Study First Submitted QC: 2011-11-29
• Study First Posted: 2011-12-01
• Status Verified: 2012-03
• Primary Completion: 2012-10
• Study Completion: 2012-12
• Last Update Submitted: 2014-02-09
• Last Update Posted: 2014-02-11

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: Male
• Target Recruitment: Not specified

Inclusion Criteria

1. Born from 1995
2. Male
3. Parents or guardian agree to attend this study
4. Undergone minor surgery (Repair of hypospadias, phimosiectomy, cryptorchidectomy or cryptorchidopexy and repair of inguinal hernia)
5. Children who scarify the No.1 to No.3 but no experience of any surgery.
6. Those who undergone minor surgery in Renji Hospital 4-6years ago.

Exclusion Criteria

1. Any congenital central nervous system diseases
2. Any congenital heart diseases
3. Any congenital dysgnosia
4. Birth weight less than 2kg
5. Ever been hypoxic encephalopathy when birth

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Wechsler Intelligence Scale for Children	Average 5 years after surgery	Wechsler Intelligence Scale for Children will be done after surgery, the expected average of 5 years after surgery.

Secondary Outcome Measures

Name	Time	Method
Achenbach Child Behavior Checklist	Average 5 years after surgery	Wechsler Intelligence Scale for Children will be done after surgery, the expected average of 5 years after surgery.

Trial Locations

Locations (1)

Renji Hospital; 🇨🇳 Shanghai, China