The effect of sertralin on the depression and of serum prolactin levels among PCOD patients
Phase 3
Recruiting
- Conditions
- E28.2Polycystic ovarian syndrome.Polycystic ovarian syndrome
- Registration Number
- IRCT20090117001556N123
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 40
Inclusion Criteria
Women with PCOS diagnosed by the Rotterdam consensus criteria (Presence of 2 of the following 3 conditions: i. amenorrhea /oligomenorrhea ii. clinical or biochemical evidence of hyperandrogenism iii. Polycystic ovaries on ultrasound examination)
Mild to moderate major depressive disorder based on DSM-5 criteria
Score on Hamilton depression scale <18
Women aged 18-60 years
Increased serum level of prolactin ( more than 20 ng per dl)
Exclusion Criteria
Psychotic symptoms
Presence of any other mental disorder
Receiving antidepressant treatment during the last 6 weeks
Breastfeeding or pregnancy
Thyroid diseases
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity of depression. Timepoint: Baseline and weeks 4 and 6 after beginning of treatment. Method of measurement: Hamiltion Depression Rating Scale 17-Item.;Serum level of prolactin. Timepoint: Baseline and weeks 4 and 6 after beginning of treatment. Method of measurement: ICMA.
- Secondary Outcome Measures
Name Time Method